中山大学学报（医学科学版）2026，Vol.47Issue(1)：84-94,11.DOI:10.11714/jsysu.med.YX20250147
类泛素化修饰在缺血性脑卒中的机制及潜在治疗靶点
The Mechanism and Potential Therapeutic Targets of SUMOylation in Ischemic Stroke
摘要
Abstract
Ischemic stroke(IS)is the second leading cause of death worldwide,characterized by high morbidity and disability rates.Small ubiquitin-related modifier(SUMO)modification,a crucial post-translational modification,plays a vital role in the pathogenesis of IS.This review elucidates the relationship between SUMOylation and IS by detailing how SUMOylation regulates key pathological processes,including neuroinflammation,mitochondrial dynamics,apoptosis,oxidative stress,and angiogenesis.Furthermore,it summarizes potential therapeutic targets of SUMOylation for IS treatment,aiming to provide new directions for clinical management.关键词
缺血性脑卒中/类泛素化修饰/病理机制/治疗靶点/综述Key words
ischemic stroke/SUMOylation/pathological mechanism/therapeutic target/review分类
医药卫生引用本文复制引用
刘楠楠,冯晓东..类泛素化修饰在缺血性脑卒中的机制及潜在治疗靶点[J].中山大学学报（医学科学版）,2026,47(1):84-94,11.基金项目
国家自然科学基金(82305364) （82305364）
