中山大学学报（医学科学版）2026，Vol.47Issue(1)：95-105,11.DOI:10.11714/jsysu.med.YX20250121
癌症骨转移免疫微环境的研究进展与治疗新策略
Advances and Novel Therapeutic Strategies in the Immune Microenvironment of Cancer Bone Metastasis
摘要
Abstract
Cancer bone metastasis is a common and lethal complication of advanced solid tumors including breast,prostate,and lung cancers,severely impacting patients'quality of life and survival outcomes.The bone metastasis microenvironment(BME)is characterized by high heterogeneity and profound immunosuppression,which serves as a fertile soil for tumor colonization and growth,and is a key reason for the poor response to conventional therapies such as chemotherapy and radiotherapy,as well as immune checkpoint inhibitors.This review systematically elaborates on the composition and functional remodeling of key cellular components within the BME,including the transformation of myeloid cells from immune surveillance cells to tumor-promoting"accomplices",the functional exhaustion of T lymphocytes(especially CD8+T cells)and the immunosuppression mediated by regulatory T cells,as well as the pathological reprogramming of bone-resident cells such as osteoclasts,osteocytes,and osteoblasts under the influence of tumor cells.The review highlights the intricate interaction networks among these cells and unveils the pivotal roles of key signaling axes,DKK1/CHI3L3,osteopontin,and TIGIT/PD-1,in mediating CD8+T cell dysfunction and facilitating local and systemic immune evasion.Based on this,this article comprehensively summarizes the emerging therapeutic strategies for this complex microenvironment,mainly including:targeting specific subsets of immune cells to reverse immunosuppression,combining multiple immune checkpoint blockades,intervening in the pathological behaviors of bone resident cells,as well as cutting-edge technical platforms such as bone-targeted drug delivery systems based on nanotechnology and engineered cell therapies.By systematically synthesizing current research advances,this review aims to provide a solid theoretical foundation and forward-looking directions for deepening the understanding of the immunology of cancer bone metastasis and developing effective and precise treatment strategies.关键词
癌症骨转移/免疫微环境/髓系细胞/免疫治疗/靶向治疗Key words
cancer bone metastasis/immune microenvironment/myeloid cells/immunotherapy/targeted therapy分类
医药卫生引用本文复制引用
陈波,瞿霞..癌症骨转移免疫微环境的研究进展与治疗新策略[J].中山大学学报（医学科学版）,2026,47(1):95-105,11.基金项目
西南医科大学校级科研项目(2021ZKQN133) （2021ZKQN133）
