中华中医药学刊2026，Vol.44Issue(1)：7-12,6.DOI:10.13193/j.issn.1673-7717.2026.01.002
甲状腺结节、乳腺增生和子宫肌瘤三病的相关性及患病规律:基于真实世界数据的研究
Correlation and Epidemiological Patterns of Thyroid Nodules,Mammary Gland Hyperplasia and Uterine Leiomyomas:A Study Based on Real-World Evidence Research
摘要
Abstract
Objective This study aims to investigate the interrelationships and disease patterns among thyroid nodules(TN),hyperplasia of mammary glands(HMG)and uterine leiomyomas(UL),providing a scientific basis for clinical diagnostic and ther-apeutic strategies,as well as rational drug use.Method A retrospective analysis was conducted on the electronic health records of female examinees who underwent thyroid,breast and uterine ultrasonography at the Health Examination Center of The First Affilia-ted Hospital of Henan University of Chinese Medicine from October 19,2011 to December 19,2018.Based on the detection re-sults,the cases with any single disease,co-occurrence of any two diseases and concurrent three diseases were included in the case group,while the individuals without any detected diseases were included in the control group.Using SPSS Statistics 22.0 software,the Cochran-Mantel-Haenszel test and descriptive statistical methods were applied to analyze the correlation and dis-ease patterns among the three diseases.Result A total of 5252 cases met the study criteria,with 2902 in the case group.The cor-relation analysis revealed significant positive associations between the co-occurrence of any two diseases.Notably,the correla-tion between TN and HMG was strongest in the 45-59 age group(r=0.106,P＜0.001),between TN and UL in the 18-44 age group(r=0.122,P＜0.001),and between HMG and UL in the 45-59 age group(r=0.157,P＜0.001).Descriptive statistical analysis indicated that the concurrence of all three diseases or any two diseases predominantly occurred in the 45-59 age range.The predominant traditional Chinese medicine(TCM)constitutions among patients were phlegm-dampness and Yang deficiency.Blood pressure,lipid and glucose levels were mostly normal but showed significant differences compared to those of the control group(P＜0.001).Laboratory tests revealed that routine blood,liver and kidney function indices were within the normal ranges,yet significantly different from those of the control group(P＜0.001).Conclusion This real-world data-based research demon-strates significant positive correlations among TN,HMG and UL,with notable differences in age distribution,TCM constitutions,blood pressure,glucose,lipids and laboratory indices compared to those of the normal group,providing crucial evidence for early detection,prevention and treatment of these diseases.关键词
甲状腺结节/乳腺增生/子宫肌瘤/数据挖掘/真实世界研究/患病规律Key words
thyroid nodules/hyperplasia of mammary gland/uterine leiomyoma/data mining/real-world evidence research/disease regularity分类
医药卫生引用本文复制引用
李春晓,张莹莹,凌霄,杨玉晴,张业,金艳涛..甲状腺结节、乳腺增生和子宫肌瘤三病的相关性及患病规律:基于真实世界数据的研究[J].中华中医药学刊,2026,44(1):7-12,6.基金项目
河南省中医药管理局中医药科学研究重点专项(2018ZY1007) （2018ZY1007）
河南省卫生健康委员会中医药科学研究专项(2022ZY1049) （2022ZY1049）
河南省高等学校重点科研项目(19A360015) （19A360015）
河南省科技攻关项目(232102310476) （232102310476）
河南省中医药拔尖人才培养项目(2022ZYBJ05) （2022ZYBJ05）
