中医临床研究2025，Vol.17Issue(30)：10-20,11.DOI:10.3969/j.issn.1674-7860.2025.30.002
中医药防治胃癌:聚焦于Correa级联反应的葡萄糖代谢重编码
Prevention and treatment of gastric cancer with traditional Chinese medicine:focusing on glucose metabolism recoding in the Correa cascade reaction
摘要
Abstract
The Correa cascade reaction represents a classic model describing the progressive development of chronic gastritis into gastric cancer,broadly categorizing gastric cancer progression into three stages:gastritis,precancerous gastric lesions,and gastric cancer.Glucose metabolic reprogramming,a hallmark feature of gastric cancer,persists throughout the entire Correa cascade reaction.During the chronic gastritis stage,the inflammatory microenvironment induced by factors such as Helicobacter pylori infection activates glycolysis and inhibits the repair of damaged gastric mucosa.In the precancerous gastric lesions stage,glucose metabolism recoding intensifies,playing a central role by suppressing apoptosis and promoting proliferation.At the stage of gastric cancer,it becomes the core driver of tumor proliferation,invasion,and drug resistance.Traditional Chinese medicine(TCM)possesses unique advantages in gastric cancer prevention and treatment through its multi-target integrated regulation.Based on the molecular mechanism of glucose metabolism recoding regulating the Correa cascade reaction,this paper systematically summarizes the latest research advances in TCM's multi-target,multi-stage regulation of glucose metabolic recoding within the Correa cascade reaction:TCM significantly modulates the activity and expression of key glucose metabolism enzymes such as hexokinase 2,pyruvate kinase M2,and lactate dehydrogenase A,directly inhibiting glycolytic flux,reducing lactate production,and promoting repair of damaged gastric mucosal cells.Active components and formulas such as astragaloside IV and berberine can inhibit key signaling pathways including PI3K/Akt/mTOR,HIF-1α,and Wnt/β-catenin pathways to reverse pro-glycolytic signaling upstream,inducing tumor cell apoptosis.Alternatively,they directly regulate the expression of genes and proteins such as c-Myc and P53,inhibiting malignant proliferation and invasion of gastric cancer cells.Furthermore,TCM indirectly modulates metabolic reprogramming by improving the tumor immune microenvironment and inducing oxidative stress.This aims to identify novel targets for gastric cancer prevention and treatment using TCM,providing reference for subsequent research.关键词
中医药/Correa级联反应/葡萄糖代谢重编码/中医治疗Key words
Traditional Chinese medicine/Correa cascade reaction/Glucose metabolism recoding/Traditional Chinese medicine treatment分类
医药卫生引用本文复制引用
龚玉霞,田思思,刘鑫月,宋琴妹,陈玉..中医药防治胃癌:聚焦于Correa级联反应的葡萄糖代谢重编码[J].中医临床研究,2025,17(30):10-20,11.基金项目
基于中医浊毒理论探讨健脾化浊解毒法调控"上皮-基质"代谢耦联逆转胃癌前状态的机制研究(23PY02). （23PY02）
