中医临床研究2025，Vol.17Issue(30)：21-26,6.DOI:10.3969/j.issn.1674-7860.2025.30.003
从"一气周流"探讨细胞焦亡与胃癌前病变的相关性
The correlation between cell death and gastric precancerous lesions from circumfluence
摘要
Abstract
Gastric precancerous lesions(GPL)represent a critical phase in gastric carcinogenesis,closely linked to the inflammation-cancer transformation.In traditional Chinese medicine(TCM),HUANG Yuanyu's circumfluence theory describes a dynamic Qi(气)movement mechanism centered on the middle Jiao(焦),supported by spleen-stomach coordination that regulates systemic Qi and blood circulation.Within this framework,GPL pathogenesis is attributed to middle Qi deficiency and pivot dysfunction,leading to imbalance in ascent-descent movement and the accumulation of dampness,phlegm,stasis,and toxins.Clinically,this theory has shown significant efficacy across the inflammation-cancer continuum.Pyroptosis,a pro-inflammatory programmed cell death process,exhibits a dual role in GPL progression:moderate activation aids immune clearance consistent with the defensive function in circumfluence,while excessive pyroptosis drives inflammatory factor release via pathways,forming a microenvironment similar to TCM's"dampness-phlegm-stasis-toxin"accumulation.Therapeutic strategies emphasize regulating the middle Jiao and restoring Qi flow,focusing on spleen reinforcement and Qi supplementation,complemented by dampness resolution and toxin removal.Modern studies indicate that spleen-strengthening herbal formulas multitarget pyroptosis pathways,inhibit NLRP3 activation,alleviate inflammation,and ameliorate gastric mucosal pathology,supporting the TCM principle of"Beinforcing healthy Qi and eliminating pathogenic factors,regulating the Qi of spleen and stomach".Investigating pyroptosis through the circumfluence theory provides a basis for TCM mechanisms and facilitates targeted interventions to reverse precancerous lesions.关键词
"一气周流"理论/细胞焦亡/胃癌前病变/炎-癌转化/中气/脾虚Key words
Circumfluence theory/Pyroptosis/Gastric precancerous lesions/Inflammation-cancer transformation/Middle Qi/Spleen deficiency分类
医药卫生引用本文复制引用
张如一,张杨,金秋宇,孙志文,荣蕾,闫舒婷,王静滨..从"一气周流"探讨细胞焦亡与胃癌前病变的相关性[J].中医临床研究,2025,17(30):21-26,6.基金项目
国家自然科学基金项目(81973601) （81973601）
黑龙江省自然科学基金项目(LH2023H059). （LH2023H059）
