中医临床研究2025，Vol.17Issue(30)：27-34,8.DOI:10.3969/j.issn.1674-7860.2025.30.004
基于共生菌群探讨生肌玉红膏"煨脓长肉"促进肛瘘术后创面修复的机制
Discussion on the mechanism of the Shengji Yuhong ointment promoting wound repair after anal fistula surgery by"promoting suppuration to regenerate flesh"based on symbiotic microbiota
摘要
Abstract
Postoperative anal fistula wounds are prone to developing into chronic wounds."Promoting suppuration to regenerate flesh"therapy of traditional Chinese medicine(TCM)demonstrates significant efficacy,though its mechanism remains unclear.Recent studies reveal that the symbiotic microbiota plays a crucial role in chronic wound healing by regulating immunity and promoting tissue regeneration.A completely sterile environment,conversely,impedes wound recovery.Currently,wound dressing changes after anal fistula surgery primarily follow the traditional moist wound healing theory.This theory posits that under sterile conditions,using moist dressings for wound management maintains wound moisture,enhances epidermal cell proliferation,differentiation,and migration,accelerates granulation tissue growth,and effectively preserves active substances in tissue exudate,thereby promoting wound healing.Simultaneously,moist dressings inhibit scab formation,minimizing mechanical damage during dressing changes and accelerating wound closure while preventing scarring.By shielding nerve endings from direct exposure to air,these dressings effectively alleviate pain caused by neural stimulation.The"Promoting suppuration to regenerate flesh"theory emphasizes the dynamic interplay between pus equilibrium and holistic Qi-blood regulation,transcending mere physical moisture retention.It not only inherits the advantages of moist wound healing in hydration,pain reduction,and scar prevention but further actively modulates pus composition and Qi-blood status through the"drug-wound interaction"mechanism.This achieves a leap from passive hydration to active regulation,significantly accelerating wound healing through dynamic equilibrium,demonstrating the unique holistic perspective and clinical utility of TCM.This study elucidates the mechanism by which the Shengji Yuhong ointment(生肌玉红膏)promotes post-anal fistula surgery wound repair through symbiotic microbiota regulation:it modulates wound microbial structure,wound pH,and the immune microenvironment(such as macrophage polarization),providing modern medical evidence for the TCM theory of"Promoting suppuration to regenerate flesh"and offering a new therapeutic strategy for post-anal fistula surgery wound care.This approach effectively enhances wound repair following anal fistula surgery.关键词
共生菌群/生肌玉红膏/煨脓长肉/肛瘘术后创面/免疫微环境Key words
Symbiotic microbiota/The Shengji Yuhong ointment/Promoting suppuration to regenerate flesh/Post-anal fistula wound/Immune microenvironment分类
医药卫生引用本文复制引用
崔西,刘翠翠,柳芹芹,李航航,翟睿,史树勋..基于共生菌群探讨生肌玉红膏"煨脓长肉"促进肛瘘术后创面修复的机制[J].中医临床研究,2025,17(30):27-34,8.基金项目
甘肃中医药大学联合科研基金项目(HXLH-XTCX01) （HXLH-XTCX01）
兰州市科技发展指导性计划项目(2024-9-83) （2024-9-83）
甘肃省高校教师创新基金项目(2025B-114). （2025B-114）
