中医临床研究2025，Vol.17Issue(30)：41-46,6.DOI:10.3969/j.issn.1674-7860.2025.30.006
滋阴活血润燥汤联合火针治疗对神经性皮炎(阴虚血瘀证)T细胞影响的研究
Research on the impact of the Ziyin Huoxue Runzao decoction combined with fire needle therapy on T-cells in neurodermatitis(Yin-deficiency and blood-stasis syndrome)patients
摘要
Abstract
Objective:To observe the clinical efficacy of the Ziyin Huoxue Runzao decoction(滋阴活血润燥汤)combined with fire needle therapy on patients with neurodermatitis[Yin(阴)-deficiency and blood-stasis syndrome]and explore its regulatory effect on T-cells.Methods:A total of 60 patients with neurodermatitis(Yin-deficiency and blood-stasis syndrome)who visited the Department of Dermatology of Ningde People's Hospital from November 1,2022,to May 31,2025 were enrolled.They were randomly assigned to the control group and the treatment group,30 cases in each group.The control group received oral administration of the Ziyin Huoxue Runzao decoction,and the treatment group was treated by needle therapy additionally.Both groups were treated for 4 weeks.Clinical efficacy,subjective/objective symptoms scores,DLQI scores,IL-6 levels,and T-cell subsets levels in the two groups were compared before and after treatment.Results:The total effective rate in the treatment group was significantly higher than that in the control group(P<0.05).After treatment,the DLQI scores and IL-6 levels were decreased significantly in both groups(P<0.05).Both groups exhibited omelioration in T lymphocyte subsets(CD8+,CD4+,and CD4+/CD8+value)compared with baseline.The treatment group showed a significantly lower CD4+/CD8+value than the control group(P＞0.05),while CD8+and CD4+levels were higher in the treatment group without statistical significance(P<0.05).Conclusion:The Ziyin Huoxue Runzao decoction combined with fire needle therapy demonstrates significant efficacy in treating neurodermatitis with Yin deficiency and blood stasis syndrome.This approach improves skin lesion conditions,mitigates inflammatory responses,and regulates immune function,is worthy of reference and application.关键词
神经性皮炎/滋阴活血润燥汤/火针/白细胞介素-6/T细胞亚群Key words
Neurodermatitis/The Ziyin Huoxue Runzao decoction/Fire needle/Interleukin-6/T cell subsets分类
医药卫生引用本文复制引用
吴菁,李丽桂,杨星兴,周露..滋阴活血润燥汤联合火针治疗对神经性皮炎(阴虚血瘀证)T细胞影响的研究[J].中医临床研究,2025,17(30):41-46,6.基金项目
宁德市自然科学基金联合项目(2022J49). （2022J49）
