摘要
Abstract
Chronic obstructive pulmonary disease(COPD)is a prevalent respiratory disorder characterized by persistent airflow limitation and respiratory symptoms.Clinically,it manifests as progressive dyspnea accompanied by chronic cough and sputum production.With a high incidence rate and notable lethality,COPD imposes a substantial burden on the health of Chinese residents and the socioeconomic landscape.Toll-like receptor 4(TLR4),a pivotal pattern recognition receptor within the innate immune system,activates the downstream nuclear factor kappa B(NF-κB)pathway by recognizing both endogenous and exogenous ligands,thereby initiating and amplifying inflammatory responses and playing a central role in the progression of COPD.Recent studies have demonstrated that the TLR4/NF-κB signaling pathway is not only involved in airway inflammatory cell infiltration and pro-inflammatory cytokine release but also mediates oxidative stress damage,protease expression imbalance,and alveolar epithelial cell apoptosis,serving as a pivotal pathway linking various pathological alterations in COPD.Traditional Chinese medicine(TCM)exhibits unique advantages in preventing and treating COPD,characterized by its multi-component,multi-target,and holistic regulatory effects.Numerous experimental studies have confirmed that various active ingredients and compound formulations of Chinese medicinal can target and modulate the TLR4/NF-κB signaling pathway,thereby inhibiting inflammatory cytokine release,alleviating oxidative damage,regulating cell apoptosis,and improving airway remodeling,ultimately delaying the progression of COPD.This article elucidates the TLR4/NF-κB signaling transduction mechanism and its pivotal role in the pathogenesis of COPD,focusing on summarizing Chinese medicinal monomers and compound formulations with the potential to regulate this pathway and exploring their underlying mechanisms.The aim is to provide novel theoretical foundations and strategies for the prevention and treatment of COPD in TCM,as well as to offer directions for the development of new TCM drugs and precise clinical medication.关键词
Toll样受体4/核转录因子-κB/慢性阻塞性肺疾病/机制/中医药/研究进展Key words
TLR4/NF-κB/Chronic obstructive pulmonary disease/Mechanism/Traditional Chinese medicine/Research progress分类
医药卫生
