摘要
Abstract
Atherosclerosis is a chronic inflammatory disease that poses a serious threat to human health.As a common pathological basis for various cardiovascular and cerebrovascular events,its high incidence and disability rates have made it a major global public health concern.Recent studies have shown that endoplasmic reticulum stress(ERS),as a critical signaling pathway activated in response to internal and external environmental disturbances,plays a central role in the initiation,progression,and plaque destabilization of atherosclerosis.Persistent ERS can disrupt the homeostasis of the unfolded protein response,trigger apoptosis in endothelial cells and macrophages,exacerbate lipid accumulation and local inflammatory responses,thereby promoting the formation and development of atherosclerotic plaques.This mechanism exhibits remarkable consistency with the pathological process described in the classical theory of traditional Chinese medicine,which states that"turbid Qi(气)returns to heart,and superfluous nutritious substances accumulates in channels".Dietary irregularities and overconsumption of rich foods impair the spleen and stomach's transforming and transporting functions,causing turbid Qi to be abnormally retained and transformed into pathogenic turbidity.This turbid Qi ascends to the heart,overflows in the vessels,and further transforms into phlegm-turbidity and blood stasis,which combine to block and congest the vessels,forming the core TCM pathogenesis of atherosclerosis.This pathological evolution complements the mechanism of ERS and apoptosis induced by oxidized low-density lipoprotein and free cholesterol accumulation in modern medicine,collectively driving disease progression and reflecting the convergence of Chinese and Western medical theories in explaining the same pathological phenomenon.Based on this,guided by the theory of"turbid Qi returns to heart,and superfluous nutritious substances accumulates in channels",this paper systematically explores the relationship between ERS and the development of atherosclerosis,and proposes a TCM treatment strategy centered on"resolving phlegm,eliminating stasis,and unblocking the vessels".By targeting the ERS signaling pathway,it offers new ideas for the prevention and treatment of atherosclerosis,while also providing a theoretical basis and practical reference for advancing the modernization and clinical application of TCM.关键词
内质网应激/细胞凋亡/浊气归心,淫精于脉/动脉粥样硬化Key words
Endoplasmic reticulum stress/Apoptosis/Turbid Qi returns to heart,and superfluous nutritious substances accumulate in channels/Atherosclerosis分类
医药卫生
