李靖泓 1夏楠 1陈宇 2梁朝源 3张李磊 1韩肖华1
作者信息
- 1. 华中科技大学同济医学院附属同济医院康复医学科,武汉 430030
- 2. 华中科技大学同济医学院附属同济医院放射科
- 3. 曼彻斯特大学电气和电子工程系
- 折叠
摘要
Abstract
Objective:To verify the long-term potential effect of acoustic-magnetic paired associative stimulation(AM-PAS)on peripheral motor output and,using functional near-infrared spectroscopy(fNIRS),to investigate the cortical functional connectivity(FC)alterations induced by AM-PAS.Methods:Totally,30 healthy right-handed volunteers were recruited and randomly assigned to either the AM-PAS or intermittent theta burst stimulation(iT-BS)group(n=15 each).Each participant underwent a single session of AM-PAS or iTBS targeting the left primary motor cortex(M1).Resting-state data were collected before and after the intervention.FC metrics were computed at the regional and hemispheric levels for within-group and between-group comparisons.In addition,the AM-PAS group underwent a separate intervention session during which motor evoked potentials(MEPs)were recorded at baseline and at 0,5,10,15,and 20 min post-stimulation to evaluate corticospinal excitability.Results:AM-PAS produced a progressive increase in MEP amplitude,with significant enhancement relative to baseline at 15 and 20 min post-stimulation(P＜0.05,0.01).In contrast to iTBS,which significantly strengthened whole-brain,inter-hemispheric,and interhemispheric connectivity(P＜0.05,0.01),AM-PAS induced a widespread reduction in corti-cal connectivity(P＜0.05,0.01).Between-group comparisons revealed significantly lower regional connectivity fol-lowing AM-PAS than iTBS,particularly within the left hemisphere(P＜0.05).Conclusion:AM-PAS effectively in-duces long-lasting enhancement of peripheral motor output for up to 20 min.Unlike iTBS,which promotes cortical coupling,AM-PAS triggers broad cortical desynchroni-zation,potentially reflecting the activation of subcorti-cal reticular circuits.These findings suggest that AM-PAS may complement existing neuromodulation tech-niques by engaging subcortical pathways,although its precise mechanisms warrant further investigation.关键词
无创神经调控技术/声磁配对刺激/重复经颅磁刺激/功能性近红外光谱/皮层功能连接Key words
non-invasive neuromodulation/acoustic-magnetic paired associative stimulation/repetitive transcrani-al magnetic stimulation/functional near-infrared spectroscopy/cortical functional connectivity分类
医药卫生
