中国康复2026，Vol.41Issue(1)：38-47,10.DOI:10.3870/zgkf.2026.01.007
经颅直流电刺激治疗神经病理性疼痛疗效的Meta分析
Efficacy of transcranial direct current stimulation for neuropathic pain:A meta-analysis
摘要
Abstract
Objective:To investigate the intervention effect of transcranial direct current stimulation(tDCS)in the treatment of neuropathic pain(NP)using meta-analysis.Methods:A computer-based search was conducted in PubMed,Web of Science,Cochrane Library,Embase,CNKI,Wanfang,VIP,and Chinese Biomedical Literature Database for randomized controlled trial(RCT)on tDCS for NP,from the inception of each database to March 2025.The quality of included literatures was evaluated using the Cochrane Handbook,Revman5.4 software was used for meta-analysis of outcome indicators including pain,depression,and anxiety,and the GRADE system was used to rate the level of evidence for research findings.Results:A total of 19 literatures involving 480 subjects were included.Meta-analysis showed that tDCS significantly reduced pain in NP patients(SMD=—0.55,95％CI:—0.73,—0.36,P＜0.01),with sustained effects at 1-month follow-up(SMD=-0.42,95％CI:-0.69,-0.15,P＜0.01)and 3-month follow-up(SMD=-0.59,95％CI:-0.94,-0.23,P＜0.01).Additionally,tDCS alleviated depression(SMD=-0.44,95％CI:—0.66,—0.22,P＜0.01)as well as anxiety(SMD=-0.43,95％CI:—0.69,—0.17,P＜0.01).Conclusion:tDCS effectively reduces pain,depression,and anxiety in NP patients with good safety.The nature of pain and stimulation site may be important factors affecting the efficacy of tDCS.关键词
经颅直流电刺激/神经病理性疼痛/Meta分析Key words
transcranial direct current stimulation/neuropathic pain/meta-analysis分类
医药卫生引用本文复制引用
赵凯旋,丁新浩,白金柱..经颅直流电刺激治疗神经病理性疼痛疗效的Meta分析[J].中国康复,2026,41(1):38-47,10.基金项目
北京市科技计划项目(Z241100007724002) （Z241100007724002）
