首页|期刊导航|National Science Open|Discovery of EP4 antagonists with image-guided explainable deep learning workflow

Discovery of EP4 antagonists with image-guided explainable deep learning workflow

Pengsen Ma Zhiyuan Cheng Zhixiang Cheng Yijie Wang Xiaolei Chai Bo Feng Hongxin Xiang Li Zeng Xueming Liu Pengyong Li Leyi Wei Quan Zou Mingyao Liu Xiangxiang Zeng Weiqiang Lu

National Science Open2025，Vol.4Issue(4)：P.11-26,16.

National Science Open2025，Vol.4Issue(4)：P.11-26,16.DOI:10.1360/nso/20240015

Discovery of EP4 antagonists with image-guided explainable deep learning workflow

Pengsen Ma ¹Zhiyuan Cheng ²Zhixiang Cheng ¹Yijie Wang ²Xiaolei Chai ²Bo Feng ³Hongxin Xiang ¹Li Zeng ⁴Xueming Liu ⁵Pengyong Li ⁶Leyi Wei ⁷Quan Zou ⁸Mingyao Liu ⁹Xiangxiang Zeng ¹Weiqiang Lu¹⁰

作者信息

1. College of Information Science and Engineering,Hunan University,Changsha 410082,China
2. Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,Shanghai 200241,China
3. Department of General Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200025,China
4. Department of AIDD,Shanghai Yuyao Biotechnology Co.,Ltd.,Shanghai 201109,China
5. Key Laboratory of Image Processing and Intelligent Control,School of Artificial Intelligence and Automation,Huazhong University of Science and Technology,Wuhan 430074,China
6. School of Computer Science and Technology,Xidian University,Xi’an 710071,China
7. School of Software,Shandong University,Jinan 250000,China
8. Institute of Fundamental and Frontier Sciences,University of Electronic Science and Technology of China,Chengdu 611731,China
9. Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,Shanghai 200241,China Department of AIDD,Shanghai Yuyao Biotechnology Co.,Ltd.,Shanghai 201109,China Hainan Academy of Medical Sciences,Hainan Medical University,Haikou 570311,China
10. Shanghai Key Laboratory of Regulatory Biology,Institute of Biomedical Sciences and School of Life Sciences,Shanghai 200241,China Hainan Academy of Medical Sciences,Hainan Medical University,Haikou 570311,China
折叠

摘要

关键词

drug discovery/PGE2 receptor subtype 4/antagonist/deep learning/computer vision

分类

医药卫生

引用本文复制引用

Pengsen Ma,Zhiyuan Cheng,Zhixiang Cheng,Yijie Wang,Xiaolei Chai,Bo Feng,Hongxin Xiang,Li Zeng,Xueming Liu,Pengyong Li,Leyi Wei,Quan Zou,Mingyao Liu,Xiangxiang Zeng,Weiqiang Lu..Discovery of EP4 antagonists with image-guided explainable deep learning workflow[J].National Science Open,2025,4(4):P.11-26,16.

基金项目

supported by the National Natural Science Foundation of China (62425204, 62122025, U22A2037, 62450002,62432011, 62250028, 81972828, 82172644, and 81830083) （62425204, 62122025, U22A2037, 62450002,62432011, 62250028, 81972828, 82172644, and 81830083）

Hunan Provincial Natural Science Foundation of China(2021JJ10020) （2021JJ10020）

National Key Scientific Infrastructure for Translational Medicine (Shanghai)(TMSK-2021-120) （Shanghai）

ECNU Multifunctional Platform for Innovation (011) （011）

National Science Open

ISSN：2097-1168

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