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Myocardial infarction creates a critical time window for AAV-based cardiac gene transfer

Gonglie Chen Yueyang Zhang Zhanzhao Liu Jingdong Wu Zhan Chen Luzi Yang Junxia Zhang Yufei Wu Jiting Li Baochen Bai Zhengyuan Lv Fei Gao Erdan Dong Yuxuan Guo

Fundamental Research2025，Vol.5Issue(6)：P.2993-3000,8.

Fundamental Research2025，Vol.5Issue(6)：P.2993-3000,8.DOI:10.1016/j.fmre.2025.06.012

Myocardial infarction creates a critical time window for AAV-based cardiac gene transfer

Gonglie Chen ¹Yueyang Zhang ¹Zhanzhao Liu ¹Jingdong Wu ²Zhan Chen ¹Luzi Yang ¹Junxia Zhang ³Yufei Wu ¹Jiting Li ¹Baochen Bai ⁴Zhengyuan Lv ¹Fei Gao ⁵Erdan Dong ⁶Yuxuan Guo⁷

作者信息

1. School of Basic Medical Sciences and Institute of Cardiovascular Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University Health Science Center,Beijing 100191,China
2. Center for Life Sciences,Institute of Molecular Medicine,College of Future Technology,Peking University,Beijing 100871,China
3. Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University,Beijing 100191,China
4. Department of Cardiology,Peking University People''s Hospital,Beijing 100044,China
5. Department of Cardiology,Beijing Anzhen Hospital,Capital Medical University,Beijing 100029,China
6. School of Basic Medical Sciences and Institute of Cardiovascular Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University Health Science Center,Beijing 100191,China Department of Cardiology and Institute of Vascular Medicine,Peking University Third Hospital,Beijing 100191,China Research Center for Cardiopulmonary Rehabilitation,University of Health and Rehabilitation Sciences Qingdao Hospital(Qingdao Municipal Hospital),School of Health and Life Sciences,University of Health and Rehabilitation Sciences,Qingdao 266071,China
7. School of Basic Medical Sciences and Institute of Cardiovascular Sciences,State Key Laboratory of Vascular Homeostasis and Remodeling,Peking University Health Science Center,Beijing 100191,China Beijing Key Laboratory of Cardiovascular Receptors Research,Beijing 100191,China
折叠

摘要

关键词

Myocardial infarction/Adeno-associated virus/Gene delivery/Gene therapy/Gene editing

分类

医药卫生

引用本文复制引用

Gonglie Chen,Yueyang Zhang,Zhanzhao Liu,Jingdong Wu,Zhan Chen,Luzi Yang,Junxia Zhang,Yufei Wu,Jiting Li,Baochen Bai,Zhengyuan Lv,Fei Gao,Erdan Dong,Yuxuan Guo..Myocardial infarction creates a critical time window for AAV-based cardiac gene transfer[J].Fundamental Research,2025,5(6):P.2993-3000,8.

基金项目

the National Science and Technology Major Project of China(2023ZD0503100 to Y.G.) （2023ZD0503100 to Y.G.）

the National Key R&D Program of China(2022YFA1104800 to Y.G.) （2022YFA1104800 to Y.G.）

Beijing Natural Science Foundation(F252059/25FS1588 to Y.G.and F.G.) （F252059/25FS1588 to Y.G.and F.G.）

the National Natural Science Foundation of China(82222006 to Y.G.,82070235 to E.D.,92168113 to E.D.and 82470343 to F.G.) （82222006 to Y.G.,82070235 to E.D.,92168113 to E.D.and 82470343 to F.G.）

the CAMS Innovation Fund for Medical Sciences(2021-I2M-5-003 to E.D.). （2021-I2M-5-003 to E.D.）

Fundamental Research

ISSN：2096-9457

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