北京中医药大学学报2026，Vol.49Issue(1)：16-23,8.DOI:10.3969/j.issn.1006-2157.2026.01.003
基于"子午流注"理论辨治溃疡性结肠炎
Differentiation and treatment strategies for ulcerative colitis based on the"midnight-noon and ebb-flow"theory
摘要
Abstract
Ulcerative colitis is a chronic relapsing inflammatory bowel disease.Modern research indicates that immune dysregulation resulting from disruptions in circadian rhythm is closely associated with its pathogenesis.Both Western chronomedicine and traditional Chinese medicine(TCM)"treatment based on temporal factors"emphasize the temporal relationship between natural rhythms and human physiology and pathology.The"midnight-noon and ebb-flow"theory represents the concrete application and deepening of TCM"treatment based on temporal factors"within the realm of chronomedicine.This article correlates the onset time of ulcerative colitis with specific periods in the"midnight-noon and ebb-flow"theory:the Mao period(05:00-07:00),when the yangming large intestine meridian of hand is dominant;the Si period(09:00-11:00),when the taiyin spleen meridian of foot is dominant;and the You period(17:00-19:00),when the shaoyin kidney meridian of foot is dominant.According to this perspective,if the disease manifests during the Mao period,the pathogenesis is attributed to dampness-heat accumulation and disorder of qi and blood.Treatment should focus on clearing heat,resolving dampness,and harmonizing qi and blood,using modified formulas such as Shaoyao Decoction or Baitouweng Decoction.If it occurs during the Si period,the pathogenesis involves spleen deficiency with dampness obstruction and disharmony of qi and blood.Treatment should focus on strengthening the spleen,eliminating dampness,and restoring qi and blood,using modified formulas such as Huangya Decoction or Shenling Baizhu Powder.If it presents during the You period,the pathogenesis is characterized by fire failing to warm earth,and consumption resulting in qi and blood leakage.Treatment should focus on warming the kidney and spleen,and securing qi and blood,using modified formulas such as Sishen Pill or Tianhun Decoction.In addition to oral administration of Chinese herbal medicine,comprehensive therapies including acupuncture,herbal enemas,and acupoint application can provide novel insights for the clinical diagnosis and treatment of ulcerative colitis.关键词
溃疡性结肠炎/子午流注/时间医学/气血Key words
ulcerative colitis/midnight-noon and ebb-flow/chronomedicine/qi and blood分类
医药卫生引用本文复制引用
孟令飞,朱超伦,赵子旭,宋冉冉,王一帆,范聪玲,米刘悦,张双喜..基于"子午流注"理论辨治溃疡性结肠炎[J].北京中医药大学学报,2026,49(1):16-23,8.基金项目
河南省科技研发计划联合基金(No.242301420114) （No.242301420114）
河南省科技攻关计划项目(No.232102311221) （No.232102311221）
河南省中医药科研专项课题(No.2025ZY3006) （No.2025ZY3006）
河南省医学科技攻关计划项目(No.LHGJ20240665) （No.LHGJ20240665）
国家中医药传承创新中心科研专项(No.2023ZXZX1088) （No.2023ZXZX1088）
郑州市医疗卫生领域科技创新指导计划项目(No.2024YLZDJH077) Joint Fund for Science and Technology Research Project of Henan Province(No.242301420114) （No.2024YLZDJH077）
