高等学校化学学报2026，Vol.47Issue(2)：59-68,10.DOI:10.7503/cjcu20250233
含两对二硫键多肽化合物的高效简便合成
Efficient and Simple Synthesis of Polypeptide Compounds Containing Two Pairs of Disulfide Bonds
摘要
Abstract
Using triphenylmethyl(Trt)and acetaminomethyl(Acm)as the protective groups of the cysteine thiol side chain,and H2O2 and I2 as oxidants,respectively,through the optimization of reaction conditions,the"one-pot"step-by-step precise synthesis of polypeptide compounds containing two pairs of disulfide bonds was achieved.This reaction strategy does not require purification of the intermediate products,is easy to operate,and has a fast reaction rate.The two pairs of disulfide bonds in the polypeptide were completely constructed within 20 minutes.The research results show that this reaction strategy has wide substrate applicability.A series of biologically active peptide compounds,including those containing tryptophan and methionine,was obtained by adopting this strategy with high overall yields.关键词
二硫键/一锅法/精准/高效/合成Key words
Disulfide bond/One-pot method/Precision/Efficient/Synthesis分类
化学化工引用本文复制引用
张滨,代先东,孟凡华,李玉龙,吕子睿..含两对二硫键多肽化合物的高效简便合成[J].高等学校化学学报,2026,47(2):59-68,10.基金项目
国家自然科学基金(批准号:22373056)和四川轻化工大学652科研创新研究团队项目(批准号:SUSE652A014)资助. Supported by the National Natural Science Foundation of China(No.22373056)and the Scientific Research and Innovation Team Program of Sichuan University of Science and Engineering,China(No.SUSE652A014). （批准号:22373056）
