临床与病理杂志2025，Vol.45Issue(10)：1281-1286,6.DOI:10.11817/j.issn.2095-6959.2025.250447
CyclinD1在胃底腺型肿瘤中的表达及其病理诊断价值
Expression of CyclinD1 in fundic gland-type tumors and its diagnostic value in pathological evaluation
凡琳琳 1江浩 1杨瑞亮 1曲延玉 1张鑫1
作者信息
- 1. 佛山市第二人民医院(广东药科大学附属佛山医院)病理科,佛山 528000
- 折叠
摘要
Abstract
Objective:Fundic gland-type tumors exhibit minimal cytological atypia,making them difficult to distinguish from fundic gland polyps and normal fundic gland mucosa.Previous studies have reported highly specific overexpression of CyclinD1 in fundic gland-type tumors,suggesting that it may serve as a useful biomarker for differential diagnosis.This study aims to characterize CyclinD1 expression patterns in fundic gland-type tumors and evaluate its diagnostic utility in pathological practice.
Methods:A total of 10 tumor specimens diagnosed as fundic gland-type tumors,13 fundic gland polyp specimens,and 15 specimens of normal fundic gland mucosa were collected from the Department of Pathology,Second People's Hospital of Foshan between January 2020 and June 2025.CyclinD1 expression was detected using the EnVision immunohistochemical method.Receiver operating characteristic(ROC)curve analysis was performed to assess the discriminatory performance of CyclinD1 for distinguishing fundic gland-type tumors from fundic gland polyps and normal mucosa.
Results:Among the 10 fundic gland-type cases,9 showed positive CyclinD1 staining,whereas only 1 of 13 fundic gland polyp cases demonstrated CyclinD1 positivity.All 15 normal fundic gland mucosa specimens were negative for CyclinD1.ROC curve analysis showed an area under the curve(AUC)of 0.950(95%confidence interval 0.838-1.062,P<0.01)for CyclinD1 in diagnosing fundic gland-type tumors.The optimal cutoff value was 0.900,yielding a sensitivity of 90% and a specificity of 100%.
Conclusion:CyclinD1 showed diffuse and strong positive expression in fundic gland-type tumors,but was rarely or not expressed in fundic gland polyps or normal fundic gland mucosa.These findings support CyclinD1 as a reliable diagnostic biomarker for fundic gland-type tumors and a valuable tool for distinguishing fundic gland-type tumors from fundic gland polyps and normal gastric mucosa.关键词
CyclinD1/胃底腺型肿瘤/鉴别诊断/胃底腺息肉/免疫组织化学/临床病理特征Key words
CyclinD1/fundic gland-type tumor/differential diagnosis/fundic gland polyp/immunohistochemistry/clinicopathological features引用本文复制引用
凡琳琳,江浩,杨瑞亮,曲延玉,张鑫..CyclinD1在胃底腺型肿瘤中的表达及其病理诊断价值[J].临床与病理杂志,2025,45(10):1281-1286,6.
