广西师范大学学报（自然科学版）2026，Vol.44Issue(2)：1-16,16.DOI:10.16088/j.issn.1001-6600.2025051801
萝藦科药用植物中新C21甾体的研究进展(Ⅱ)
Research Progress of New C21 Steroids in Medicinal Plants of Asclepiadaceae(Ⅱ)
摘要
Abstract
C21 steroids are a class of steroid derivatives containing 21 carbon atoms in the parent nucleus.They have many pharmacological activities such as anti-tumor,immune enhancement,anti-oxidation,anti-epilepsy,and hypolipidemic,and demonstrating significant medicinal value.Asclepiadaceae plants are one of the main sources of natural C21 steroids.According to the relevant literature,nearly 913 new C21 steroidal compounds were isolated from Asclepiadaceae in the past 20 years.According to the number,properties and degree of unsaturation of the substituents on the skeleton,their structures were divided into 9 types(Ⅰ-Ⅸ),of which type Ⅰ was pregnane and type Ⅱ-Ⅸ was deformed pregnane.Pregnane and deformed pregnane differ in spatial structure,biological activity and metabolic pathway,which makes deformed pregnane become the focus of drug development and chemical biology research.In this paper,the distribution,physicochemical properties and spectral characteristics of type Ⅱ-Ⅸ modified pregnane were introduced.关键词
萝藦科/孕甾烷/结构特征/理化性质Key words
Asclepiadaceae/pregnane/structural characteristics/physicochemical property分类
医药卫生引用本文复制引用
徐秀虹,张进燕,卢羽玲,梁小平,廖广凤,卢汝梅..萝藦科药用植物中新C21甾体的研究进展(Ⅱ)[J].广西师范大学学报（自然科学版）,2026,44(2):1-16,16.基金项目
国家自然科学基金(82360823) （82360823）
广西自然科学基金青年基金(2025GXNSFBA069359) （2025GXNSFBA069359）
广西高校中青年教师科研基础能力提升项目(2025KY0365) （2025KY0365）
广西特色中药现代产业学院大学生创新创业训练计划立项项目(C202404) （C202404）
