广西医学2026，Vol.48Issue(1)：19-27,9.DOI:10.11675/j.issn.0253-4304.2026.01.03
衰老过程中睾丸免疫稳态的变化及干细胞在恢复睾丸免疫稳态的应用潜力
Changes in testicular immune homeostasis during aging and application potential of stem cells in restoring testicular immune homeostasis
摘要
Abstract
The testis is a core organ of the male reproductive system.The blood-testis barrier,the local immunosuppressive microenvironment,and various immune cells collectively constitute the testicular immune microenvironment.The unique immune microenvironment of the testis maintains testicular immune homeostasis through multiple cellular and molecular mechanisms,which is crucial for ensuring the normal operation of endocrine and spermatogenic functions of the testis.However,during the aging process,significant changes occur in testicular immune homeostasis,primarily manifested as a chronic low-grade inflammatory state and alterations in the composition and function of immune cell subsets.The imbalance of testicular immune homeostasis can further exacerbate testicular aging.This paper introduces the mechanisms maintaining testicular immune homeostasis,analyzes the changes in testicular immune homeostasis during aging and their impact on male reproductive function,and further explores the application prospects of stem cell therapy in restoring testicular immune homeostasis.关键词
睾丸免疫稳态/衰老/睾丸衰老/免疫细胞/干细胞/综述Key words
Testicular immune homeostasis/Aging/Testicular aging/Immune cells/Stem cells/Review分类
医药卫生引用本文复制引用
何湧洺,吴优,陈志宏,邓春华..衰老过程中睾丸免疫稳态的变化及干细胞在恢复睾丸免疫稳态的应用潜力[J].广西医学,2026,48(1):19-27,9.基金项目
国家自然科学基金面上项目(82570930、82371609、82171564) （82570930、82371609、82171564）
