广西医学2026，Vol.48Issue(1)：80-84,5.DOI:10.11675/j.issn.0253-4304.2026.01.10
血清尿酸/肌酐值与子痫前期患者不良妊娠结局的相关性
Correlation between serum uric acid-to-creatinine ratio and adverse pregnancy outcomes in patients with preeclampsia
摘要
Abstract
Objective To explore the correlation between serum uric acid-to-creatinine(SUA/Cr)ratio and adverse pregnancy outcomes in patients with preeclampsia(PE).Methods Clinical data of 146 PE patients were retrospectively analyzed.Based on the presence of adverse perinatal pregnancy outcomes,patients were divided into adverse pregnancy outcome group(n=40)or normal pregnancy group(n=106).Clinical data were compared between the two groups.Logistic regression model was adopted to identify factors influencing adverse pregnancy outcomes in PE patients.Receiver operating characteristic curves were plotted,and the area under the curve(AUC)was used to evaluate the predictive value of independent risk factors for adverse pregnancy outcomes.Spearman correlation was performed to analyze the correlation between the SUA/Cr value and adverse pregnancy outcomes.Results(1)Compared with the normal pregnancy group,the adverse pregnancy outcome group exhibited higher systolic blood pressure,diastolic blood pressure,24-hour urinary total protein,SUA level,and a greater SUA/Cr value at admission,as well as a greater systolic-to-diastolic ratio(S/D)of the fetal umbilical artery within one week before delivery,along with a lower serum albumin level at admission(P<0.05).(2)Multivariate Logistic regression analysis results indicated that 24-hour urinary total protein at admission,SUA/Cr value at admission,and S/D value within one week before delivery were independent risk factors for adverse pregnancy outcomes in PE patients(P<0.05).(3)The AUC of SUA/Cr value at admission,24-hour urinary total protein level at admission,and S/D value within one week before delivery for predicting adverse pregnancy outcomes in PE patients were 0.890,0.833,and 0.703,respectively.The optimal cutoff values were 7.185,327 mg,and 2.285,with sensitivities of 78.3%,64.2%,and 72.5%,and specificities of 87.5%,87.5%,and 67.0%,respectively.(4)The SUA/Cr value at admission positively correlated with the occurrence risk of adverse pregnancy outcomes in PE patients(P<0.05).Conclusion The SUA/Cr value at admission positively correlates with the occurrence risk of adverse pregnancy outcomes in PE patients and exerts predictive value for such outcomes to a certain extent.关键词
子痫前期/不良妊娠结局/血清尿酸/肌酐值/相关性Key words
Preeclampsia/Adverse pregnancy outcomes/Serum uric acid-to-creatinine ratio/Correlation分类
医药卫生引用本文复制引用
余益香,王琳,闻明..血清尿酸/肌酐值与子痫前期患者不良妊娠结局的相关性[J].广西医学,2026,48(1):80-84,5.基金项目
安徽省临床重点专科建设项目(皖卫传[2023]320号) （皖卫传[2023]320号）
芜湖市科技计划项目(2022cg35) （2022cg35）
