中医学报2026，Vol.41Issue(2)：258-264,7.DOI:10.16368/j.issn.1674-8999.2026.02.036
中医休粮疗法对肥胖型多囊卵巢综合征患者肠道菌群的影响
Effect of Traditional Chinese Medicine Fasting Therapy on Gut Microbiota in Obese Patients with Polycystic Ovary Syndrome
摘要
Abstract
Objective:To explore the effect of traditional Chinese medicine fasting therapy on the gut microbiota of obese patients with polycystic ovary syndrome(PCOS).Method:Obese PCOS patients who completed traditional Chinese medicine fasting therapy at Yang-ming Road Outpatient Department of Jiangxi University of Chinese Medicine Affiliated Hospital from December 2021 to July 2022 were selected as the research subjects.Compare the changes and distribution characteristics of gut microbiota diversity among 7 subjects be-fore,after 1 month,and after 3 months of fasting therapy.Results:(1)Alpha diversity analysis:Compared with before fasting therapy,the Ace index and Chao index of patients decreased after one month of fasting therapy(P<0.05).(2)Colony composition analysis:At the phylum level,compared with before fasting therapy,the relative abundance of Firmicutes decreased after one month of fasting thera-py,while the abundance of Bacteroidetes,Actinobacteria,Proteobacteria,and Fusobacteria increased.The differences were not statistical-ly significant(P>0.05);Compared with before fasting therapy for3 months,the abundance of Firmicutes,Actinobacteria,Proteobacte-ria,and Clostridium decreased,while the abundance of Bacteroidetes increased,but the differences were not statistically significant(P>0.05).In terms of genus level,the abundance of Bacteroides significantly increased(P<0.05)after one month and three months of fasting therapy compared with that before fasting therapy.The abundance of Roseburia was significantly lower after one month of fast-ing therapy than before fasting therapy(P<0.05),and the abundance increased after three months of fasting therapy compared with one month of fasting therapy(P<0.05).(3)LEfSe analysis:Before fasting therapy,the Saccharimonadia,Saccharimonadaales,Sac-charimonadaceae,Patescibacteria,TM7x,Adlercreutzia,Roseburia,Lachnospira,Eubacterium-brachy_group,Negativibacillus,and Eu-bacterium-creditiosum-g groups in the group showed relative abundance advantages;After one month of fasting therapy,the Bacte-roides,Bacteroidaceae,Enterococcaceae,and Enterococcus genera showed relative abundance advantages in the group.Conclusion:Tra-ditional Chinese Medicine's fasting therapy has a significant regulatory effect on the gut microbiota of obese PCOS patients,which may regulate the body's metabolism by affecting the production of short chain fatty acids.关键词
肥胖型多囊卵巢综合征/中医休粮疗法/肠道菌群Key words
obses patients with polycystic ovary syndrome/traditional Chinese medicine fasting therapy/gut microbiota分类
医药卫生引用本文复制引用
何孟阳,岳梦锦,查青林,林色奇..中医休粮疗法对肥胖型多囊卵巢综合征患者肠道菌群的影响[J].中医学报,2026,41(2):258-264,7.基金项目
江西省科技厅重点研发计划项目(20171ACG70011) （20171ACG70011）
