河南中医2026，Vol.46Issue(2)：220-227,8.DOI:10.16367/j.issn.1003-5028.2026.02.0036
基于铁死亡、炎症和氧化应激探讨参芪地黄汤治疗糖尿病肾病研究进展
Research Progress on the Treatment of Diabetic Kidney Disease with Ginseng and Astragalus and Rehmannia Decoction Based on Ferroptosis and Inflammation and Oxidative Stress
摘要
Abstract
Ginseng and Astragalus and Rehmannia Decoction,as a representative formula for treating diabetic kidney disease(DKD),may exert its therapeutic effects through potential mechanisms including:regulating the expression of genes related to iron and lipid me-tabolism via its antioxidant effects;inhibiting key regulators of ferroptosis such as hypoxia-inducible factor-1α and tumor suppressor pro-tein p53,etc.;and enhancing antioxidant enzyme activity to block lipid peroxidation,thereby mitigating ferroptosis-mediated cellular damage.However,research in this field is still in its infancy and currently faces the following challenges:(1)The mechanism research requires further depth.Although preliminary research has elucidated some of the pharmacodynamic mechanisms of Ginseng and Astraga-lus and Rehmannia Decoction,more in-depth molecular biology experiments are needed to systematically explain its precise regulation of ferroptosis-related genes and signaling pathways,as well as the synergistic effects of its multiple components.(2)Combined therapy strategies urgently need exploring.Given the complexity of DKD pathogenesis,single therapeutic approaches often have limitations.Fu-ture studies should focus on exploring combined application strategies for Ginseng and Astragalus and Rehmannia Decoctio with Western medicine,other Chinese medicinal compounds,or TCM external therapies to achieve synergistic effects through multiple pathways,there-by providing patients with more optimized treatment options.(3)Clinical evidence-based is lacking.Current research is predominantly limited to animal experiments,and there is a lack of high-quality clinical research data.In the future,it is necessary to conduct large-scale clinical trials to confirm the human efficacy of this decoction in treating DKD by inhibiting ferroptosis.A thorough elucidation of the specific mechanisms by which Ginseng and Astragalus and Rehmannia Decoction regulates ferroptosis will aid in exploring its poten-tial for treating various diseases and provide new insights and targets for clinical translation.关键词
糖尿病肾病/铁死亡/炎症/氧化应激/参芪地黄汤Key words
diabetic kidney disease(DKD)/ferroptosis/inflammation/oxidative stress/Ginseng and Astragalus and Rehmannia Decoc-tion分类
医药卫生引用本文复制引用
秦嘉恒,时黛,王霄霄,顾雯,杨照康,侯静..基于铁死亡、炎症和氧化应激探讨参芪地黄汤治疗糖尿病肾病研究进展[J].河南中医,2026,46(2):220-227,8.基金项目
贵州省卫生和计划生育委员会科学技术基金项目(gzwjkj2014-2-120) （gzwjkj2014-2-120）
贵州中医药大学研究生教育创新计划项目(YcxkYs2023032) （YcxkYs2023032）
