基础医学与临床2026，Vol.46Issue(2)：155-163,9.DOI:10.16352/j.issn.1001-6325.2026.02.0155
综合性多组学硅肺病数据平台SilicosisOmics的构建
SilicosisOmics:an integrated multi-omics platform for silicosis
摘要
Abstract
Objective To address the challenges of fragmented multi-omics data and insufficient integrated analysis in silicosis research,we aim to construct a comprehensive data platform that supports systematic analysis of multi-level molecular alterations in fibrotic lung tissues and facilitates rapid identification of therapeutic targets.Methods We systematically integrated transcriptomic,single-cell transcriptomic,quantitative proteomic,post-translational modification-specific proteomic,and metabolomic data from human and mouse silicotic and control lung tissues.By leveraging bioinformatics tools including DESeq2,Seurat,and CellChat,we developed a web-based visualization platform enabling data visualization and interactive analysis.Results We successfully constructed SilicosisOmics(https://respir.pumc.edu.cn/SilicosisOmics/),a comprehensive multi-omics data platform for silicosis research.The platform integrated five types of omics data derived from both silicotic and non-diseased lung tissues across human and mouse species.SilicosisOmics provided not only online search functionality for static visualiza-tion of gene expression and single-cell clustering but also interactive analytical tools supporting user-customized analyses including differential gene expression,pathway enrichment,and cell-cell interaction studies.Conclusions The SilicosisOmics platform offers systematic multi-omics data resources and user-friendly analytical tools for silicosis and pulmonary fibrosis research,thereby facilitating the advancement of mechanistic studies,target discovery,and subsequent translational research.关键词
硅肺病/肺纤维化/多组学/数据平台/数据共享Key words
silicosis/pulmonary fibrosis/multi-omics/data platform/data sharing分类
生物科学引用本文复制引用
王季馨,黄鑫磊,齐先梅,张田甜,庞军玲,龙尔平,王婧..综合性多组学硅肺病数据平台SilicosisOmics的构建[J].基础医学与临床,2026,46(2):155-163,9.基金项目
癌症、心脑血管、呼吸和代谢性疾病防治研究国家科技重大专项(2024ZD0528904) （2024ZD0528904）
国家自然科学基金(82100080) （82100080）
中国医学科学院医学与健康科技创新工程(2021-I2M-1-049,2023-I2M-2-001) （2021-I2M-1-049,2023-I2M-2-001）
北京高校卓越青年科学家计划(BJZQ2024002) （BJZQ2024002）
全国重点实验室专项基金(2060204) （2060204）
