基础医学与临床2026，Vol.46Issue(2)：193-199,7.DOI:10.16352/j.issn.1001-6325.2026.02.0193
利拉鲁肽降低心肌梗死大鼠心功能损伤及房颤易感性
Liraglutide decreases cardiac function damage and atrial fibrillation susceptibility in rats with myocardial infarction
摘要
Abstract
Objective To investigate the effects of liraglutide on myocardial inflammation and cardiac function in rats with acute myocardial infarction(AMI),and to further explore its effects on susceptibility to atrial fibrillation and the underlying mechanisms.Methods The rats were divided into the sham operation group(sham group),the AMI group(using the method of coronary arteryligation),and the liraglutide group(AMI+LIR group).Rats in the AMI+LIR group were intraperitoneally injected with liraglutide at a dose of 250 μg/(kg·d).The sham group and the AMI group were injected with an equal amount of normal saline.Four weeks later,echocardiography was used to evaluate the cardiac structure and function of the rats;electrocardiogram was collected and electrophysiological de-tection was performed to evaluate the susceptibility to atrial fibrillation;HE staining and Masson staining were used to detect the morphology of myocardial cells and the degree of myocardial fibrosis;the enzyme-linked immunosor-bent assay(ELISA)was used to detect the levels of interleukin-1β(IL-1β),interleukin-6(IL-6),and interleu-kin-18(IL-18);Western blot was used to detect the protein expressions of NLRP3,Caspase-1,and GSDMD in the myocardial tissues.Results Compared with the sham group,the degree of myocardial fibrosis and the infiltra-tion of inflammatory cells in the myocardial tissue of the rats in the AMI group increased significantly;the left at-rial diameter(LAD),the left ventricular posterior wall thickness after diastole(LVPWd),and the left ventricu-lar end-diastolic diameter(LVEDd)were significantly increased,while the left ventricular fractional shortening(FS)and the left ventricular ejection fraction(LVEF)were significantly decreased(P＜0.05);The P-wave du-ration(PWD),PR interval(PRI),and maximum absolute fibrillation duration(MAFD)increased,while the atrial effective refractory period(AERP)was decreased;the levels of inflammatory factors IL-6,IL-18,IL-1β and the protein expressions of NLRP3,Caspase-1,and GSDMD were significantly increased(P＜0.05).Com-pared with the AMI group,the myocardial fibrosis and inflammatory infiltration in the AMI+LIR group were improved;the LAD,LVPWd,and LVEDd were significantly decreased,while the FS and LVEF were signifi-cantly increased;the levels of inflammatory factors IL-6,IL-18,IL-1β and the protein expressions of NLRP3,Caspase-1,and GSDMD were significantly decreased(P＜0.05).Conclusions Liraglutide can reduce myo-cardial fibrosis and inflammation,improve cardiac function,and decrease the susceptibility to atrial fibrillation in rats with AMI.关键词
心肌梗死/房颤/利拉鲁肽/心肌电活动Key words
myocardial infarction/atrial fibrillation/liraglutide/myocardial electrical activity分类
医药卫生引用本文复制引用
李静薇,张润峰..利拉鲁肽降低心肌梗死大鼠心功能损伤及房颤易感性[J].基础医学与临床,2026,46(2):193-199,7.基金项目
四川省科技计划支持项目(2020YJ0495) （2020YJ0495）
绵阳市卫生健康委员会基金(202117) （202117）
