江苏大学学报（医学版）2026，Vol.36Issue(1)：24-29,6.DOI:10.13312/j.issn.1671-7783.y250062
基于18F-FDG PET/CT的棕色脂肪组织特征参数与冠状动脉钙化的相关性分析
Correlation between 18F-FDG PET/CT-derived brown adipose tissue characteristics and coronary artery calcification
摘要
Abstract
Objective:To investigate the correlation between the characteristic parameters of brown adipose tissue(BAT)and coronary artery calcification in 18F-FDG PET/CT images.Methods:A total of 2 399 patients who underwent 18F-FDG PET/CT examination at the Affiliated Hospital of Jiangsu University from December 2013 to April 2024 were collected.After 1∶1 propensity score matching(PSM),the patients were divided into BAT positive group(n=171)and BAT negative group(n=171)according to whether BAT was positive.Differences in general clinical data and the incidence of coronary artery calcification between the two groups were analyzed.Differences in BAT imaging characteristic parameters among six anatomical sites(the neck,supraclavicular fossa,axilla,mediastinum,paravertebral region,and abdomen)in patients of the BAT-positive group were analyzed,and the site with the highest BAT activity(the paravertebral region)was screened out.Furthermore,differences in paravertebral BAT imaging characteristic parameters among groups with different numbers of coronary artery calcification-involved branches and different severities of coronary artery calcification were analyzed.Results:After PSM,the incidence of coronary artery calcification and the coronary artery calcium score in the BAT positive group were significantly lower than those in the BAT negative group.In the BAT positive group,the SUVmax of paravertebral BAT was the highest among the six anatomical sites,and the difference was statistically significant compared with the SUVmax of abdominal and axillary BAT(all P＜0.001).The SUVmean of paravertebral BAT significantly differed from that of axillary BAT(P＜0.001),but showed no significant differences with other anatomical sites(all P＞0.05).Both the volume and surface area of paravertebral BAT demonstrated statistically significant differences compared to abdominal and axillary BAT(all P＜0.001).As both the number of coronary artery branches involved and the severity of calcification increased,all characteristic parameters of paravertebral BAT progressively decreased(all P＜0.01).Conclusion:The presence of BAT is associated with a lower risk of coronary artery calcification.Paravertebral BAT may have a potential inhibitory effect on the occurrence and development of coronary artery calcification.关键词
棕色脂肪组织/18F-FDG PET/CT/冠状动脉钙化/倾向性评分匹配Key words
brown adipose tissue/18F-FDG PET/CT/coronary artery calcification/propensity score matching分类
医药卫生引用本文复制引用
杨浩,朱海涛,易义德,宋廉,张龙江,曹雄锋..基于18F-FDG PET/CT的棕色脂肪组织特征参数与冠状动脉钙化的相关性分析[J].江苏大学学报（医学版）,2026,36(1):24-29,6.基金项目
镇江市重点研发计划社会发展项目(SH2023017) （SH2023017）
江苏大学医教协同创新基金项目(JDY2023003) （JDY2023003）
江苏省社会发展面上项目(BE2023759) （BE2023759）
