江苏大学学报（医学版）2026，Vol.36Issue(1)：58-64,7.DOI:10.13312/j.issn.1671-7783.y250043
METRNL基因多态性与2型糖尿病的相关性
Association between the polymorphisms of METRNL gene and type 2 diabetes mellitus
摘要
Abstract
Objective:To investigate the association between the polymorphisms of meteorin-like protein(METRNL)gene rs4986080 and type 2 diabetes mellitus(T2DM).Methods:A total of 467 subjects were selected,including 315 T2DM patients and 152 individuals with normal glucose tolerance(NGT).The polymerase chain reaction-restriction fragment length polymorphism(PCR-RFLP)method was used to detect the polymorphisms of METRNL gene rs4986080 in all subjects,then analyzed the association between these polymorphisms and T2DM.Results:The constituent ratio of GG genotype and the frequency of G allele at rs4986080 locus of METRNL gene was higher in the T2DM group compared to the NGT group(P＜0.05).Compared to individuals with GG genotype at the METRNL gene rs4986080 locus,those with AA+AG genotypes showed significant lower waist-to-hip ratio,fasting plasma glucose(FPG),2-hour postprandial glucose(2hPG),glycated hemoglobin(HbA1c),and homeostasis model assessment of insulin resistance(HOMA-IR)(P＜0.05).Logistic regression analysis showed that A allele at rs4986080 locus of METRNL gene was probably a protective factor for T2DM.Conclusion:The polymorphisms of METRNL gene rs4986080 may be associated with the occurrence of T2DM,and A allele may be a protective factor for T2DM.关键词
镍纹样蛋白/单核苷酸多态性/2型糖尿病/胰岛素抵抗Key words
meteorin-like protein/single nucleotide polymorphism/type 2 diabetes mellitus/insulin resistance分类
医药卫生引用本文复制引用
肖瑞峰,袁国跃,贾珏,吴旭楠,邓霞,王兆祥,沈聪,沈雯,赵丽,杨玲..METRNL基因多态性与2型糖尿病的相关性[J].江苏大学学报（医学版）,2026,36(1):58-64,7.基金项目
江苏省高层次卫生人才"六个一工程"项目(LGY2016053) （LGY2016053）
江苏省第六期"333高层次人才培养工程"("卡脖子"技术)(BRA2022008) （"卡脖子"技术）
