内蒙古民族大学学报（自然科学版）2026，Vol.41Issue(1)：19-28,10.DOI:10.14045/j.cnki.15-1220.2026.01.003
单细胞组学揭示缺血性脑卒中微环境的免疫异质性
Single-Cell Omics Reveals the Immune Heterogeneity of the Microenvironment in Ischemic Stroke
摘要
Abstract
Ischemic stroke(IS)is one of the leading causes of death and disability.Recent studies have shown that the pathological processes following a stroke are not only limited to blood flow obstruction,but also involve complex immune cell functions,such as the regulation of inflammatory responses and brain tissue repair and remodeling.The innate immune cells in the brain and peripheral immune cells play multiple roles at different stages of stroke.Although traditional research methods such as flow cytometry and transcriptome sequencing have revealed the basic information of immune responses,they are unable to deeply analyze the heterogeneity and spatial distribution of cells.The emergence of single-cell omics has provided new perspectives for studying post-stroke immune cell subpopulations,lineage differentiation trajectories,and intercellular interaction networks,has greatly promoted the in-depth understanding of the immune mechanism of stroke.This paper reviews the application progress of single-cell omics technologies in the study of the immune microenvironment in ischemic stroke,focusing on elaborating its research achievements in immune cell recognition and heterogeneity analysis,tracking dynamic changes in the immune microenvironment,intercellular interactions(including cross-lineage interactions),and the discovery of related therapeutic targets,also discusses the challenges in current research and the future development directions,which providing new references for the basic research and clinical translation of ischemic stroke.关键词
缺血性脑卒中/单细胞组学/免疫微环境Key words
ischemic stroke/single-cell omics/immune microenvironment分类
医药卫生引用本文复制引用
周若水,金花,塔娜,张东威..单细胞组学揭示缺血性脑卒中微环境的免疫异质性[J].内蒙古民族大学学报（自然科学版）,2026,41(1):19-28,10.基金项目
内蒙古自治区直属高校基本科研业务费项目(GXKY22043) （GXKY22043）
内蒙古自治区自然科学基金项目(2024QN08083) （2024QN08083）
内蒙古自治区卫生健康委员会中医药(蒙医药)科技计划课题(ZMY-2024107) （蒙医药）
内蒙古自治区自然科学基金项目(2025LHMS08041) （2025LHMS08041）
内蒙古自治区高等学校科学研究项目(NJZY21435) （NJZY21435）
2025年通辽市科技创新专项资金(重点研发和成果转化项目)(TL2025YF013) （重点研发和成果转化项目）
