日用化学工业（中英文）2026，Vol.56Issue(2)：176-184,9.DOI:10.3969/j.issn.2097-2806.2026.02.005
O/W型水杨酸微乳的制备与质量评价
Preparation and evaluation of O/W microemulsions containing salicylic acid
摘要
Abstract
The O/W microemulsions containing salicylic acid were prepared and evaluated.Isopropyl myristate was used as the oil phase and a mixture of Tween 80 and polyethylene glycol 400(1:1)was used as the mixed surfactants.The microemulsion formulation was optimized by solubility analysis,pseudo-ternary phase diagram construction,and central composite design-response surface methodology.The results showed that,the optimized formulation,consisting of 5%oil phase and 42.7%surfactant mixture,achieved a maximum drug-loading capacity of 48.303 mg/g.The microemulsion thus prepared was a transparent,clear O/W liquid with particle size of(7.66±0.31)nm and polydispersity index of 0.11±0.04,demonstrating excellent thermal and freeze-thaw stabilities.In vitro release experiments showed that the microemulsion exhibited sustained release of salicylic acid in different media,with cumulative release rates approaching 82%to 96%over 48 hours,which was significantly higher than those of free salicylic acid.In addition,in vitro tyrosinase inhibition assays indicated that the microemulsion enhanced the bioavailability of salicylic acid,achieving inhibition rate of over 95%when the salicylic acid content was 0.5%or more.In conclusion,the optimized microemulsion formulation had superior drug-loading capacity,stability,and sustained-release characteristics,effectively improving the therapeutic efficacy of salicylic acid.This microemulsion system was proposed as a potential drug delivery carrier,which might offer new technical support for the clinical application of salicylic acid.关键词
水杨酸/微乳/紫外分光光度法/伪三元相图/星点设计-响应面法Key words
salicylic acid/microemulsion/ultraviolet spectrophotometry/pseudo-ternary phase diagram/central composite design-response surface method分类
化学化工引用本文复制引用
赵洋,王艳,唐文杰,任硕晗,张桂红,李疆改..O/W型水杨酸微乳的制备与质量评价[J].日用化学工业（中英文）,2026,56(2):176-184,9.基金项目
国家自然科学基金项目(81602773) （81602773）
现代中医药海河实验室科技计划项目(24HHZYSS00009) （24HHZYSS00009）
天津市自然科学基金重点项目(24JCZDJC00720) （24JCZDJC00720）
现代中药创制全国重点实验室开放课题(CBCM2025208) （CBCM2025208）
