日用化学工业（中英文）2026，Vol.56Issue(2)：217-225,9.DOI:10.3969/j.issn.2097-2806.2026.02.010
基于AHP-EWM联合赋权优化补骨脂酚脂质体的制备及其延缓皮肤衰老作用
Based on the AHP-EWM combined weighting optimization:preparation of bakuchiol liposomes and its effect on delaying skin aging
摘要
Abstract
In this study,we evaluated encapsulation efficiency,particle size,zeta potential,and polydispersity index(PDI)as key indicators.We combined the Analytic Hierarchy Process(AHP)with the Entropy Weight Method(EWM)to assign scientific weights to these indicators.Based on response surface methodology,we optimized the liposome preparation process and characterized the liposome morphology using transmission electron microscopy(TEM)and other techniques.Experimental verification identified the optimal liposome preparation conditions:a hydration time of 45 minutes,a lecithin-to-bavachin mass ratio of 8∶1,a hydration temperature of 45℃,and a lecithin-to-cholesterol mass ratio of 4∶1.Under these conditions,the liposome particle size is(177.52±5.22)nm,the PDI is 0.36±0.05,and the Zeta potential is(-45.60±3.68)mV,indicating uniform particle size distribution,good stability,and appropriate surface charge.We used UVA-irradiated human skin fibroblasts(HSF)to establish a photoaging cell model and evaluated cell viability through CCK-8 testing.We also analyzed photoaging damage and drug intervention effects by detecting reactive oxygen species(ROS),superoxide dismutase(SOD),and catalase(CAT).Results show that a UVA radiation dose of 5 J/cm2 effectively induces cellular photoaging.Bakuchiol liposomes(Bak-lip)exhibit no significant toxicity at the concentrations of 0-10 μg/mL and significantly reduce intracellular ROS levels in photoaged cells while enhancing SOD and CAT activities,with the most significant effects at 5 μg/mL(p<0.05).Compared to free bakuchiol,Bak-lip improves the water solubility of bakuchiol due to its bilayer liposome structure.This structure effectively encapsulates the hydrophobic bakuchiol and protects it from activity loss caused by environmental factors,enabling more stable antioxidant function.关键词
补骨脂酚/脂质体/光老化/层次分析法(AHP)/熵权法(EWM)Key words
bakuchiol/liposomes/photoaging/AHP/EWM分类
化学化工引用本文复制引用
万鹏鹤,吕宁,毛明慧,于海英,薛超越,李启艳..基于AHP-EWM联合赋权优化补骨脂酚脂质体的制备及其延缓皮肤衰老作用[J].日用化学工业（中英文）,2026,56(2):217-225,9.基金项目
国家药品监督管理局化妆品标准研究(2021-BZ-014) （2021-BZ-014）
山东省药品监督管理局药品医疗器械化妆品检验检测能力提升项目(SDNMPAFZLY202205) （SDNMPAFZLY202205）
山东省重点研发计划(乡村振兴科技创新提振行动计划)项目(2022TZXD004) （乡村振兴科技创新提振行动计划）
