日用化学品科学2026，Vol.49Issue(2)：21-25,5.DOI:10.3969/j.issn.1006-7264.2026.02.005
药用植物身体用霜抑制基质金属蛋白酶的研究
Study on the inhibitory effects of a medicinal plant-based body cream on matrix metalloproteinases
张泽奇 1韦姜好 2康天怿 2韩春霞 3李楚欣 3李凯2
作者信息
- 1. 深圳市容大生物科技股份有限公司,广东 深圳 518000||广东省天然植物源先导化合物化妆品工程技术研究中心,广东 深圳 518000||东莞市容大生物科技有限公司,广东 东莞 523808
- 2. 南方科技大学 生物医学工程系,广东 深圳 518055
- 3. 深圳市容大生物科技股份有限公司,广东 深圳 518000||广东省天然植物源先导化合物化妆品工程技术研究中心,广东 深圳 518000
- 折叠
摘要
Abstract
This study evaluated the inhibitory effects of Guanghua Cream,an anti-aging body cream formulated with medicinal plants,on matrix metalloproteinases(MMPs).A UV-induced photoaging model was established on the dorsal skin of mice,followed by topical application of the cream to irradiated areas for several weeks.Subsequently,MMP levels in skin and blood,catalase(CAT)activity,collagen content in skin,and histological analyses of five major organs were performed.Results showed that Guanghua Cream downregulated UV-induced expression of MMP-1 and MMP-9 in skin and inhibited collagen fiber degradation,while enhancing CAT expression to exert antioxidant effects.The cream also suppressed MMP-1,MMP-3,and MMP-9 levels in blood,potentially contributing to delayed aging.H&E staining of mouse organs revealed no abnormalities,indicating that Guanghua Cream has high biological safety.关键词
衰老/基质金属蛋白酶/过氧化氢酶Key words
aging/matrix metalloproteinases/catalase分类
化学化工引用本文复制引用
张泽奇,韦姜好,康天怿,韩春霞,李楚欣,李凯..药用植物身体用霜抑制基质金属蛋白酶的研究[J].日用化学品科学,2026,49(2):21-25,5.
