陕西师范大学学报（自然科学版）2026，Vol.54Issue(1)：52-63,12.DOI:10.15983/j.cnki.jsnu.2026006
膳食甜味剂影响运动对肥胖及多器官代谢紊乱的改善研究进展
Research progress of exposure to sweeteners affecting exercise-induced improvement in combating obesity and metabolic dysfunctions
摘要
Abstract
Exercise ameliorates obesity-induced fat accumulation,insulin resistance and inflammatory response through AMPK/SIRT1/PPARs signaling pathways,yet its efficacy may be modulated by dietary factors.Notably,the excessive consumption of sugar adversely affects host health.The substitution of high-calorie sucrose with low-calorie functional sweeteners has gained widespread popularity among sports enthusiasts and people seeking for weight reduction.Nevertheless,the intricate relationship between sweeteners and host energy metabolism,fat metabolism,and immune health remains largely unexplored.Given the pivotal roles played by exercise and functional sweetener intake in the physiology of obesity and its related complications,we systematically reviewed the impacts of exercise on mitigating obesity-induced dysfunctions across multiple organs(e.g.,cardiovascular,cerebral vascular,hepatic,renal,intestinal,skeletal muscle,and adipose tissues).Moreover,impacts of distinct sweeteners on core regulating targets(e.g.,AMPK/SIRT1/PPARs,STAT3/NF-κB/Smad,PI3K/Akt signaling pathways)of exercise for combating obesity and its related metabolic diseases were then summarized to illustrate potential synergistic or antagonistic effects of sweeteners on the health effects of exercise.This review furnishes theoretical basis and practical guidance aiming for optimization of exercise strategies that could successfully prevent obesity and improve weight maintenance.关键词
肥胖/运动/高糖摄入/甜味剂/分子机制Key words
obesity/exercise/high-sugar consumption/sweeteners/molecular mechanism分类
社会科学引用本文复制引用
刘源,吕佳瑶,朱婉瑜,屈毅哲,施琳..膳食甜味剂影响运动对肥胖及多器官代谢紊乱的改善研究进展[J].陕西师范大学学报（自然科学版）,2026,54(1):52-63,12.基金项目
西安市农业攻关项目(23NYGG0056) （23NYGG0056）
陕西省科技厅创新能力支撑计划科技创新团队项目(2022TD-14) （2022TD-14）
