Abstract
Objective To explore the correlation between immune function,coagulation function indicators and spinal mobility in patients with ankylosing spondylitis(AS).Methods A total of 150 AS patients who visited Characteristics Medical Center of Chi-nese People's Armed Police Force from November 2019 to November 2024 were selected and divided into an active stage group and a stable stage group according to Bath Ankylosing Spondylitis Disease Activity Index(BASDAI).The levels of indicators related with co-agulation and fibrinolytic activity,platelet count(PLT),erythrocyte sedimentation rate(ESR),C-reactive protein(CRP),factors re-lated with thrombosis,Th17/Treg and related factors,and oxidative stress indicators were compared between the two groups.The cor-relations between BASDAI,Bath Ankylosing spondylitis Functional Index(BASFI)and the above indicators was analyzed.Results Compared with the stable stage group,the levels of fibrinogen(FIB),D-dimer,PLT,fibrin degradation products(FDP),thrombin A2(TXA2),plasminogen activator inhibitor(PAI),ESR,CRP,Th17,Th17/Treg,interleukin(IL)-17,IL-23 and ma-londialdehyde(MDA)were higher in the active stage group,while the levels of activated partial thromboplastin time(APTT),prosta-cyclin(PGI2),Treg,IL-10,transforming growth factor-β(TGF-β),superoxide dismutase(SOD),and catalase(CAT)were lower(P<0.05);Correlation analysis showed that BASDAI and BASFI in AS patients were positively correlated with D-dimer,PLT,FDP,TXA2,PAI,ESR,CRP,Th17,Th17/Treg,IL-17,IL-23,and MDA,and negatively correlated with APTT,PGI2,Treg,IL-10,TGF-β,SOD and CAT(P<0.05).Conclusions The coagulation function,immune function and oxidative stress indicators in AS pa-tients are closely related with the disease activity and spinal mobility.关键词
强直性脊柱炎/凝血功能/免疫/脊柱活动度/相关性Key words
ankylosing spondylitis/coagulation function/im-munity/spinal mobility/correlation分类
医药卫生
