武警医学2026，Vol.37Issue(1)：48-53,6.
热应激下武装越野后血小板活化及其参数变化与心肌损伤的相关性
Correlation between platelet activation and its parameters changes and myocardial injury under heat stress during armed cross-country running
摘要
Abstract
Objective To explore the effects of armed cross-country running under heat stress on platelet activation and its pa-rameters,and to analyze the potential relationship between these changes and myocardial injury.Methods A total of 93 male soldiers who participated in a 10-km armed cross-country running under high-temperature conditions from July 2023 to July 2024 were included.The P-selectin and platelet parameters of the subjects were detected before and after training,as well as 4 hours and 16 hours after training.The changes of related indicators were compared.According to the cTnI levels,the subjects were grouped,and Spearman cor-relation analysis was used to analyze the changes(Δ)of P-selectin and platelet parameters and their association with myocardial inju-ry.Logistic regression was used to analyze the influencing factors of myocardial injury.Results A total of 86 soldiers completed the training without experiencing symptoms such as chest tightness,palpitations,and persistent fever.41 participants showed elevated cTnI 4 h after training,which decreased significantly 16 h after training,with a statistically significant difference compared to 4 h after train-ing(P<0.05).Compared with pre-training levels,P-selectin levels at the end of training were significantly elevated[261.7(198.6,355.2)vs.1060.9(808.0,2740.9)pg/ml](P<0.05),platelet count(PLT)and platelet-large platelet count(P-LCC)also in-creased significantly,as did platelet hematocrit(PCT)(P<0.05).After blood volume correction,cPLT and cP-LCC at the end of training remained elevated compared to pre-training levels.Subjects were divided into a normal group(n=45)and a myocardial injury group(n=41)based on whether cTnI levels were elevated 4 h after training.Compared with the normal group,the myocardial injury group had higher ΔP-selectin levels[628.2(418.7,774.9)vs.2404.9(1885.7,2900.4)pg/ml],while lower ΔcPLT and ΔPCT levels(P<0.05).ΔP-selectin was positively correlated with myo-cardial injury,while ΔcPLT and ΔPCT were negatively correlated with myocardial injury,and the differences were statistically signifi-cant(P<0.05).ΔP-selectin was a risk factor for myocardial injury,while ΔPCT was a protective factor(P<0.05).Conclusions Military training under heat stress can cause changes in platelet activation and its parameters,as well as reversible sub-clinical myocardial injury.ΔP-selectin(platelet activation degree)is an important risk factor for myocardial injury,ΔcPLT and ΔPCT are significantly correlated with myocardial injury,with lower ΔPCT levels associated with a higher risk of myocardial injury.关键词
热应激/军事训练/血小板活化/血小板参数/心肌损伤Key words
heat stress/military training/platelet activation/platelet parameters/myocardial injury分类
医药卫生引用本文复制引用
黎斌兵,洪绍彩,赵芬,陆艳玲,沈文雅,黄富登,贝俊杰..热应激下武装越野后血小板活化及其参数变化与心肌损伤的相关性[J].武警医学,2026,37(1):48-53,6.基金项目
武警部队某课题资助 （）
