现代妇产科进展2026，Vol.35Issue(1)：35-41,7.DOI:10.13283/j.cnki.xdfckjz.2026.01.006
妊娠期糖尿病孕妇中性粒细胞/淋巴细胞比值轨迹分析及与新生儿胎龄体重相关性研究
Dynamic trajectory of neutrophil/lymphocyte ratio in pregnant women with gestational diabetes mellitus and correlation with neonatal weight for gestational age
摘要
Abstract
Objective:To investigate the longitudinal trajectory of neutrophil/lympho-cyte ratio(NLR)in pregnant women with gestational diabetes mellitus(GDM)and its correla-tion with neonatal weight for gestational age.Methods:The data of 335 pregnant women with GDM and their newborns who underwent labor and delivery in our hospital between January 2024 and November 2024 were retrospectively analyzed.NLR levels were collected from all GDM pregnant women at 6～13+6 weeks of gestation,14～19+6 weeks of gestation,20～23+6 weeks of gestation,24～28 weeks of gestation,30～32 weeks of gestation,34～36 weeks of ges-tation,and 37～41 weeks of gestation at the time of pregnancy checkup.Growth mixture model-ing(GMM)was used to identify potential category trajectories of NLR in pregnant women with GDM.According to the delivery gestational week and birth weight,neonates were classified into small for gestational age(SGA),appropriate for gestational age(AGA)and large for gestational age(LGA),and the clinical characteristics of each group were compared,and the effect of NLR trajectories on neonatal gestational age and weight was analyzed by multifactorial logistic regres-sion and ROC curves.Results:There was an overall increasing trend in NLR levels during preg-nancy in GDM pregnant women(F=338.70,P<0.001).Three NLR trajectory subtypes in GDM pregnant women were fitted based on GMM:low NLR slowly rising in 89 cases(26.6%),low NLR rapidly rising in 193 cases(57.6%)and high NLR slowly rising in 53 cases(15.8%).There were 29(8.7%)SGA,187(55.8%)AGA and 119(35.5%)LGA in the newborns.Differences in age,BMI,education level,percentage of hypothyroidism,maternal type,TG,TC and NLR trajectories were statistically significant when comparing pregnant women with GDM in the three gestational age groups(P<0.05).Multifactorial logistic regression analy-sis showed that age and education level were common influences on SGA and LGA(P<0.05).TG and hypothyroidism were independent influences on SGA(P<0.05).BMI,maternal type,and NLR trajectory were independent influences on LGA(P<0.05).The results of the ROC curve analysis showed that the predictive value of NLR trajectory for LGA was higher.Conclu-sion:NLR in GDM pregnant women showed three trajectories of low NLR slowly rising type,low NLR rapidly rising type and high NLR slowly rising type during gestation,and high NLR slowly rising type was associated with an increased risk of LGA.Dynamic monitoring of the NLR level may provide a reference for the early prediction of abnormal gestational age weight.关键词
妊娠期糖尿病/中性粒细胞/淋巴细胞比值/轨迹/大于胎龄儿/小于胎龄儿Key words
Gestational diabetes mellitus/Neutrophil/lymphocyte ratio/Trajectory/Large for gestational age/Less-than-gestational-age infant分类
医药卫生引用本文复制引用
蒋秀敏,殷郑娜,穆梦露,梅莉,王常宏..妊娠期糖尿病孕妇中性粒细胞/淋巴细胞比值轨迹分析及与新生儿胎龄体重相关性研究[J].现代妇产科进展,2026,35(1):35-41,7.基金项目
安徽省卫生健康委科研项目(No:AHWJ2021b119) （No:AHWJ2021b119）
