协和医学杂志2026，Vol.17Issue(1)：1-9,9.DOI:10.12290/xhyxzz.2025-1018
从机体失调反应重新认知肿瘤重症
Reconceptualizing Critical Illness in Cancer Through the Lens of Host Unregulated Response
摘要
Abstract
Onco-critical care has emerged as an important subspecialty at the intersection of critical care medicine and oncology,attracting increasing attention in recent years.With continuous innovations in cancer therapies,patient survival has improved significantly;however,the incidence of associated critical complications has also increased.The reasons for cancer patients requiring intensive care unit admission are di-verse and can be broadly categorized into three groups:progression of the underlying malignancy,treatment-re-lated complications,and coexisting classical critical illnesses.Traditional critical care concepts and practices face limitations in addressing the multidimensional and heterogeneous challenges of onco-critical care.Based on the core mechanism of critical illness development—host/organ unregulated response(HOUR)—this article systematically elaborates on how this framework advances understanding and clinical practice into onco-critical care,with emphasis on its manifestations in neuroendocrine,immune-inflammatory,and coagulation-metabolic pathways.The review summarizes recent advances in clinical assessment and phenotyping systems for onco-criti-cal illness and discusses a multidisciplinary,integrated management strategy centered on the"Disease Control,Host Response Modulation,Organ Support"triad.Finally,major challenges and future directions in this field are outlined.By integrating existing evidence and theoretical insights,this review aims to provide new perspec-tives and a theoretical foundation for the clinical management of onco-critical illness,thereby promoting its evo-lution toward precision and standardization.关键词
肿瘤重症/机体失调反应/精准医学/多学科协作Key words
oncology intensive care medicine/host unregulated response/precision medicine/multidisci-plinary team分类
医药卫生引用本文复制引用
褚赟,巩师毅,丁欣,赵华,陈焕,张青,王小亭..从机体失调反应重新认知肿瘤重症[J].协和医学杂志,2026,17(1):1-9,9.基金项目
四大慢病重大专项(2024ZD0562100) Noncommunicable Chronic Diseases-National Science and Technology Major Project(2024ZD0562100) （2024ZD0562100）
