畜牧兽医学报2026，Vol.57Issue(1)：46-57,12.DOI:10.11843/j.issn.0366-6964.2026.01.005
色氨酸代谢产物调控肠道氧化应激研究进展
Research Progress on Tryptophan Metabolites in Alleviating Intestinal Oxidative Stress
摘要
Abstract
The gastrointestinal tract is not only a place where nutrients digest,absorb and metabolize,but also serves as both a primary source and a major target of reactive oxygen species(ROS).Intestinal health is a cornerstone of animal growth and a critical determinant of livestock production efficiency.Tryptophan,an essential amino acid,is metabolized by both host cells and gut microbiota into various bioactive compounds,such as indole,kynurenine and 5-hydroxytryptamine.These metabolites act as endogenous ligands to regulate intestinal oxidative stress and inflammatory damage.This review summarizes the host and microbial pathways of intestinal tryptophan metabolism,explores the physiological functions of tryptophan metabolites in modulating oxidative stress and tissue repair,and discusses the role of microbial tryptophan metabolism in potential nutritional interventions,including probiotics and nutritional supplements.These findings aim to inform research on nutritional strategies for managing gut health.关键词
肠道/氧化应激/色氨酸代谢/肠道微生物/营养调控Key words
intestine/oxidative stress/tryptophan metabolism/intestinal microorganisms/nutritional regulation分类
农业科技引用本文复制引用
孟云龙,邓远坤,谭碧娥,王婧..色氨酸代谢产物调控肠道氧化应激研究进展[J].畜牧兽医学报,2026,57(1):46-57,12.基金项目
湖南省科技创新计划资助(2024RC3188) （2024RC3188）
国家自然科学基金(32102571) （32102571）
