畜牧兽医学报2026，Vol.57Issue(1)：96-107,12.DOI:10.11843/j.issn.0366-6964.2026.01.009
冠状病毒辅助蛋白功能研究进展
Research Progress on the Functions of Coronavirus Accessory Proteins
摘要
Abstract
The RNA genome of coronavirus contains multiple open reading frames,coding for structural proteins,non-structural proteins,as well as accessory proteins.The accessory proteins of coronavirus are species specific,and the amounts of accessory proteins differ between the species.Coronavirus accessory proteins are not necessary for viral replication,but some of them are involved in the host immune response,viral pathogenesis and virus virulence.Research on coronavirus accessory proteins will provide new potential targets for the development of therapeutic drugs and theoretical guidance for disease prevention and treatment.In this paper,the functions of several representative accessory proteins of coronaviruses are reviewed.It focuses on the relationship between accessory proteins and virus-host interactions,including the role of accessory proteins in promoting host cell apoptosis,host innate immune regulation,and pathogenicity in the host.This will help to investigate the infection and pathogenesis of coronavirus,and provide reference for developing new vaccines and antiviral drugs.关键词
冠状病毒/辅助蛋白/细胞凋亡/天然免疫/致病性/疫苗Key words
coronavirus/accessory protein/cell apoptosis/innate immunity/pathogenicity/vaccine分类
农业科技引用本文复制引用
赵秀美,赵海娜,华姝,程旭,陈祥,姜逸..冠状病毒辅助蛋白功能研究进展[J].畜牧兽医学报,2026,57(1):96-107,12.基金项目
江苏农林职业技术学院科技项目(2021kj25) （2021kj25）
江苏省自然科学基金面上项目(BK20241979) （BK20241979）
江苏省人兽共患病学重点实验室资助项目(R2306) （R2306）
