畜牧兽医学报2026，Vol.57Issue(1)：108-119,12.DOI:10.11843/j.issn.0366-6964.2026.01.010
沙门菌耐药基因水平转移机制及影响因素
Mechanisms and Influencing Factors of Horizontal Transfer of Drug-resistant Genes in Salmonella
摘要
Abstract
Salmonella is a common foodborne pathogen worldwide.With the promotion and use of antibiotics,more and more Salmonella produce or acquire antibiotic resistance genes(ARG)through vertical transmission and horizontal gene transfer(HGT),causing widespread dissemination of antibiotic resistance.In the process of horizontal gene transfer,ARGs are mainly carried by mobile genetic elements(MGEs),which are important mediators of HGT and can facilitate the spread of ARGs.Among them,MGEs mainly include plasmids,integrons and conjugative elements,transposons,insertion sequences,and phages,etc.MGE-associated transfer mechanisms,accessory gene compositions,and relationships between ARG dissemination and animal sources and geographic environments vary.The aim of this review is to outline the HGT mechanism of ARG in Salmonella,the different MGE-mediated HGT mechanisms and the influencing factors of HGT occurrence and development,which is of great significance for the in-depth investigation of the HGT mechanism of drug resistance in Salmonella.关键词
沙门菌/水平基因转移/抗生素耐药基因/移动遗传元件Key words
Salmonella/horizontal gene transfer/antibiotic resistance gene/mobile genetic element分类
农业科技引用本文复制引用
孙泽远,向令娴,李琳,左儒楠..沙门菌耐药基因水平转移机制及影响因素[J].畜牧兽医学报,2026,57(1):108-119,12.基金项目
国家重点研发计划项目(2024YFE0106300) （2024YFE0106300）
安徽省自然科学基金面上项目(2208085MC79) （2208085MC79）
安徽省教育厅自然科学基金重点项目(2023AH051017) （2023AH051017）
