临床研究2026，Vol.34Issue(2)：1-5,5.DOI:10.12385/j.issn.2096-1278(2026)02-0001-05
NHHR与急性冠脉综合征合并2型糖尿病患者冠脉多支病变的相关性研究
Association Between the Non-High-Density Lipoprotein Cholesterol to High-Density Lipoprotein Cholesterol Ratio and Multivessel Coronary Artery Disease in Patients With Acute Coronary Syndrome and Type 2 Diabetes Mellitus
邱睿 1李子衿 1李东升2
作者信息
- 1. 江汉大学 医学部,湖北 武汉 430056||武汉市第三医院(武汉大学同仁医院) 心血管内科,湖北 武汉 430060
- 2. 武汉市第三医院(武汉大学同仁医院) 心血管内科,湖北 武汉 430060
- 折叠
摘要
Abstract
Objective To investigate the association between the non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio(NHHR)and multivessel coronary artery disease(MVD)in patients with acute coronary syndrome(ACS)complicated by type 2 diabetes mellitus(T2DM).and to evaluate its predictive value for coronary MVD.Methods A total of 378 patients with ACS and concomitant T2DM who were admitted to Wuhan Third Hospital between January 2022 and December 2024 were enrolled.Based on coronary angiography findings.the patients were divided into a single-vessel disease group(SVD.n=111)and a multivessel disease group(MVD.n=267).Differences in clinical characteristics.biochemical indices.and NHHR between the two groups were compared.Spearman correlation analysis was used to assess the correlation between NHHR and MVD.Multivariable logistic regression was performed to identify independent factors associated with MVD in this population.Receiver operating characteristic(ROC)curves were generated to evaluate the predictive performance of NHHR for MVD.Results Significant between-group differences were observed in sex.fasting plasma glucose(FPG).white blood cell count(WBC).neutrophil count(N).total cholesterol(TC).triglycerides(TG).high-density lipoprotein cholesterol(HDL-C).low-density lipoprotein cholesterol(LDL-C).platelet count(PLT).NHHR.and hemoglobin A1c(HbA1c)(P＜0.05).Multivariable regression analysis showed that a high NHHR(OR=2.268.95%CI 1.533～3.355.P＜0.001)and HbA1c(OR=1.551.95%CI 1.215～1.979.P＜0.001)were independent factors associated with MVD in patients with ACS and T2DM.ROC analysis showed that NHHR predicted MVD with an area under the curve(AUC)of 0.727.a sensitivity of 0.588.and a specificity of 0.802.HbA1c predicted MVD with an AUC of 0.677.a sensitivity of 0.442.and a specificity of 0.847.The combined model of NHHR and HbA1c yielded an AUC of 0.758.with a sensitivity of 0.760 and a specificity of 0.649.Conclusion NHHR is positively correlated with the presence of MVD in patients with ACS complicated by T2DM and shows certain predictive value for multivessel disease.When combined with HbA1c.its predictive performance is higher than that of either indicator alone.关键词
急性冠脉综合征/2型糖尿病/非高密度脂蛋白胆固醇与高密度脂蛋白胆固醇比值/多支病变Key words
acute coronary syndrome/type 2 diabetes mellitus/non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio/multivessel disease分类
医药卫生引用本文复制引用
邱睿,李子衿,李东升..NHHR与急性冠脉综合征合并2型糖尿病患者冠脉多支病变的相关性研究[J].临床研究,2026,34(2):1-5,5.
