临床研究2026，Vol.34Issue(2)：20-23,4.DOI:10.12385/j.issn.2096-1278(2026)02-0020-04
外周血炎症指标与肿瘤标志物对食管癌T分期的判别价值分析
Diagnostic Value of Peripheral Blood Inflammatory Indicators and Tumor Markers for T-Stage Discrimination in Esophageal Cancer
苏熙 1王艳敏1
作者信息
- 1. 安阳市肿瘤医院 医学检验科,河南 安阳 455000
- 折叠
摘要
Abstract
Objective To investigate differential expression patterns of peripheral blood inflammatory indicators and tumor markers across different T stages of esophageal cancer and to evaluate their value in diagnosing T stage in patients with esophageal cancer.Methods Clinical and laboratory data of 100 patients with esophageal cancer diagnosed and treated at Anyang Cancer Hospital between January 2024 and January 2025 were retrospectively analyzed.According to T stage.patients were divided into a T1～T2 group(n=62)and a T3～T4 group(n=38).Levels of peripheral blood inflammatory indicators and tumor markers were compared between the two groups.Variance inflation factor(VIF)was used to assess multicollinearity.and non-collinear variables were entered into multivariable Logistic regression analysis to identify independent factors associated with T stage.Receiver operating characteristic(ROC)curves were constructed to evaluate the diagnostic performance of individual indicators and their combination.Results Compared with the T1～T2 group.patients in the T3～T4 group had significantly higher platelet count(PLT).neutrophil-to-lymphocyte ratio(NLR).platelet-to-lymphocyte ratio(PLR).systemic immune-inflammation index(S Ⅱ).C-reactive protein(CRP).serum amyloid A(SAA).fibrinogen(FIB).and the tumor markers squamous cell carcinoma antigen(SCC-Ag).cytokeratin 19 fragment(CYFRA21-1).and carbohydrate antigen 19-9(CA19-9)(P＜0.05).After collinearity assessment.NLR.PLR.and PLT were excluded.and the remaining indicators were included in the multivariable Logistic regression analysis.The results showed that SⅡ and CYFRA21-1 were independent risk factors for T3～T4 stage.ROC analysis indicated that the areas under the curve(AUC)for SⅡ and CYFRA21-1 in diagnosing T3～T4 stage were 0.892 and 0.868.respectively.whereas the combined AUC reached 0.928.with higher sensitivity and specificity.Conclusion Peripheral blood inflammatory indicators and tumor markers differ significantly across T stages in esophageal cancer.S Ⅱ and CYFRA21-1 are independent indicators for advanced T stage.and their combined assessment may help improve the diagnostic performance for T staging in esophageal cancer.关键词
食管癌/肿瘤标志物/T分期/系统性免疫炎症指数/细胞角蛋白19片段Key words
esophageal cancer/tumor markers/T stage/systemic immune-inflammation index/cytokeratin 19 fragment分类
医药卫生引用本文复制引用
苏熙,王艳敏..外周血炎症指标与肿瘤标志物对食管癌T分期的判别价值分析[J].临床研究,2026,34(2):20-23,4.
