临床研究2026，Vol.34Issue(2)：24-27,4.DOI:10.12385/j.issn.2096-1278(2026)02-0024-04
基于超声与代谢-炎症指标探讨急性脑梗死患者脑小血管病负荷的影响因素
Exploring Factors Influencing Cerebral Small Vessel Disease Burden in Patients With Acute Cerebral Infarction Based on Ultrasound and Metabolic-Inflammatory Indicators
苏方欣 1解德富 1刘洁煜 1王坤 1潘延克1
作者信息
- 1. 南阳医学高等专科学校第一附属医院 急诊科,河南 南阳 473000
- 折叠
摘要
Abstract
Objective To investigate factors influencing the burden of cerebral small vessel disease(CSVD)in patients with acute cerebral infarction and to evaluate the value of carotid and transcranial Doppler ultrasonography(TCD/TCCD)parameters in stratifying CSVD burden.Methods A total of 106 patients with acute cerebral infarction diagnosed at the First Affiliated Hospital of Nanyang Medical College from May 2022 to March 2025 were enrolled.According to CSVD burden assessment.they were assigned to a low-burden group(n=64)or a high-burden group(n=42).Baseline characteristics.laboratory indicators.carotid ultrasound findings.and TCD/TCCD parameters were compared between the two groups.Logistic regression analysis was performed to identify independent risk factors for high CSVD burden.Results The high-burden group had significantly higher levels of fasting plasma glucose(FPG).glycated hemoglobin(HbA1c).total cholesterol(TC).homocysteine(Hcy).uric acid(UA).and C-reactive protein(CRP)than the low-burden group(P＜0.05).The mean carotid intima-media thickness(cIMT).total plaque area.common carotid artery pulsatility index(CCA-PI).and common carotid artery resistance index(CCA-RI)were significantly increased in the high-burden group(P＜0.05).TCD/TCCD findings showed that the pulsatility index(PI)and resistance index(RI)of the middle cerebral artery(MCA-PI and MCA-RI).the pulsatility index of the anterior cerebral artery(ACA-PI).and the pulsatility index of the basilar artery(BA-PI)were all significantly higher in the high-burden group(P＜0.05).Multivariable logistic regression analysis indicated that each 10 μmol/L increase in UA.each 1 mmol/L increase in TC.and each 0.1-unit increase in CCA-RI.MCA-PI.or ACA-PI were independent risk factors for high CSVD burden(P＜0.05).Conclusion Metabolic-inflammatory indicators and ultrasound parameters.including UA.TC.CCA-RI.MCA-PI.and ACA-PI.are independent risk factors for high CSVD burden and may serve as useful reference indicators for assessing CSVD burden in patients with acute cerebral infarction.关键词
急性脑梗死/脑小血管病/颈动脉超声/经颅多普勒Key words
acute cerebral infarction/cerebral small vessel disease/carotid ultrasonography/transcranial Doppler ultrasonography分类
医药卫生引用本文复制引用
苏方欣,解德富,刘洁煜,王坤,潘延克..基于超声与代谢-炎症指标探讨急性脑梗死患者脑小血管病负荷的影响因素[J].临床研究,2026,34(2):24-27,4.
