中国肺癌杂志2025，Vol.28Issue(11)：841-848,8.DOI:10.3779/j.issn.1009-3419.2025.101.21
粪菌移植:肺癌治疗的潜在途径
Fecal Microbiota Transplantation:A Promising Avenue for Lung Cancer Therapy
摘要
Abstract
As lung cancer treatment continues to advance,mainstream approaches such as surgery,radiotherapy,chemotherapy,neoadjuvant therapy,targeted therapy and immunotherapy have become widely adopted in clinical practice.However,the efficacy of these methods is still limited and they are associated with significant side effects.In recent years,the pivotal role of the gut microbiota in tumor immune regulation has become increasingly recognized,with its potential impact on tumor immunotherapy emerging as a novel therapeutic focus in lung cancer management.Against this backdrop,fecal microbi-ota transplantation(FMT)has been proposed as a potential immunomodulatory strategy.It enhances host immune responses and improves the tumor immune microenvironment by regulating the gut microbiota.This paper provides a systematic review of the latest research advances in FMT for lung cancer treatment.Focusing on the relationship between gut microbiota and lung cancer,the therapeutic mechanisms of FMT and clinical application studies,it provides a comprehensive exploration of the challenges and prospects for the use of FMT in lung cancer therapy.关键词
肺肿瘤/粪菌移植/肠道微生物Key words
Lung neoplasms/Fecal microbiota transplantation/Gut microbiota引用本文复制引用
洪修雯,邓雅倩,冯娇,鲍翠,张源源,高楠,沈红..粪菌移植:肺癌治疗的潜在途径[J].中国肺癌杂志,2025,28(11):841-848,8.基金项目
This paper was supported by the grant from Nanjing Medical Science and Technology Development Fund Project(No.YKK16226)(to Hong SHEN). 本文受南京市医学科技发展基金项目(No.YKK16226)资助 （No.YKK16226）
