中国肺癌杂志2025，Vol.28Issue(11)：849-856,8.DOI:10.3779/j.issn.1009-3419.2025.101.20
肠道菌群基于脑-肠轴影响肺癌脑转移的作用机制研究进展
Research Progress on the Mechanism of Gut Microbiota Influencing Lung Cancer Brain Metastasis via the Brain-gut Axis
摘要
Abstract
Lung cancer,one of the leading causes of cancer-related deaths worldwide,severely influences patients'quality of life and prognosis due to its complication of brain metastasis(primarily involving the brain parenchyma).While traditional treatments such as surgery,radiotherapy,and chemotherapy have demonstrated efficacy in clinical practice,their ap-plication remains limited due to toxicity and patient tolerance issues.Emerging targeted therapies and immunotherapies,which exhibit significant efficacy with fewer side effects,still face challenges including partial drug resistance and genetic mutations.In recent years,research on the association between gut microbiota and lung cancer brain metastasis has gained prominence.Its mechanism of action may influence the progression of brain metastasis through multidimensional interactions via the brain-gut axis,involving neuroendocrine and immune pathways.This review examines specific mechanisms by which gut microbiota modulate lung cancer brain metastasis through immune regulation,endocrine-metabolic regulation,and neurotransmitter con-trol via the brain-gut axis,as well as therapeutic and traditional medicine research on regulating gut microbiota in lung cancer brain metastasis.It aims to provide theoretical support and identify potential clinical therapeutic targets for the prevention and treatment of lung cancer brain metastasis.关键词
肺肿瘤/肠道菌群/脑转移/脑-肠轴/作用机制Key words
Lung neoplasms/Gut microbiota/Brain metastasis/Brain-gut axis/Mechanism of action引用本文复制引用
李丹,陈亮,吕鹏强,杨全石,杨建新,安德明,余雨,高国明..肠道菌群基于脑-肠轴影响肺癌脑转移的作用机制研究进展[J].中国肺癌杂志,2025,28(11):849-856,8.基金项目
This paper was supported by the grants from Gansu Provincial Traditional Chinese Medicine Research Project(No.GZKG-2022-59)(to Deming AN),Tianshui Municipal Science and Technology Project(No.2022-SHFZKJK-1165)(to Liang CHEN)and the Tianshui Municipal"Chengji Star"Talent Project(Municipal Organization Circular[2024]No.25)(to Jianxin YANG). 本文受甘肃省中医药科研立项课题(No.GZKG-2022-59)、天水市科技支撑计划项目(No.2022-SHFZKJK-1165)和天水市"成纪之星"人才项目(市组通字[2024]25号)资助 （No.GZKG-2022-59）
