中国防痨杂志2026，Vol.48Issue(2)：167-187,21.DOI:10.19982/j.issn.1000-6621.20250435
抗结核药治疗药物监测临床应用专家共识(2025年更新版)
Expert consensus on therapy and drug monitoring clinical application of anti-tuberculosis drug(updated in 2025)
摘要
Abstract
Therapeutic drug monitoring(TDM)is a method to develop individualized dosing regimens for patients based on the measurement of drug exposure pharmacological biomarkers,or efficacy indicators in the body,using quantitative pharmacological models and taking the drug treatment window as the benchmark.Its core is individualized drug therapy.In order to further guide and standardize the TDM work of anti-tuberculosis drugs in Chinese medical institutions,ensuring scientific rigor,ethical practice,and standardized procedures for maximal patient benefit,Pharmaceutical Professional Branch of Chinese Antituberculosis Association,in conjunction with Beijing Chest Hospital,Capital Medical University/Beijing Tuberculosis and Thoracic Tumor Research Institute systematically updated the indications,monitoring methods,dose adjustment,and application in special populations of TDM on the basis of the 2021 Expert consensus on clinical application of therapeutic drug monitoring for anti-tuberculosis drugs.This consensus is registered on the international practice guidelines platform,and the formulation process follows the principles of methodology.Drawing on the collaborative expertise of tuberculosis pharmaceutical and clinical experts,along with the latest evidence-based research and practical experience,this consensus will provide scientific and feasible guidance for the clinical implementation of TDM.关键词
结核/药物监测/治疗应用/指南Key words
Tuberculosis/Drug monitoring/Therapeutic uses/Guidebooks分类
医药卫生引用本文复制引用
中国防痨协会药学专业分会,首都医科大学附属北京胸科医院/北京市结核病胸部肿瘤研究所,陆宇..抗结核药治疗药物监测临床应用专家共识(2025年更新版)[J].中国防痨杂志,2026,48(2):167-187,21.基金项目
国家自然科学基金(82173862) （82173862）
北京市登峰人才计划(DFL20221402) National Natural Science Foundation of China(82173862) （DFL20221402）
Beijing Municipal Administration of Hospitals' Ascent Plan(DFL20221402) （DFL20221402）
