中国临床药理学杂志2025，Vol.41Issue(23)：3301-3308,8.DOI:10.13699/j.cnki.1001-6821.2025.23.001
CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与新疆地区T2DM患者二甲双胍疗效的关联性研究
Association study of CAPN10 rs3792269 and SLC47A2 rs12943590 genetic polymorphisms with metformin efficacy in T2DM patients in Xinjiang region
摘要
Abstract
Objective To investigate the association between CAPN10 rs3792269 and SLC47A2 rs12943590 gene polymorphisms and the efficacy of metformin in type 2 diabetes mellitus(T2DM)patients receiving metformin monotherapy in Xinjiang,providing references for individualized drug therapy in local patients.Methods A total of 450 T2DM patients who had been regularly taking metformin monotherapy for ≥3 months from July 2024 to July 2025 in a tertiary hospital in Xinjiang were selected.Clinical data were collected and target locus genotypes were detected.Using glycated hemoglobin(HbA1c％)as the efficacy indicator,patients were divided into wild-type homozygous and mutant genotype groups.Propensity score matching(PSM)was employed to analyze the association between gene polymorphisms and efficacy,followed by post hoc power analysis.Results The PSM analysis revealed that the CAPN10 rs3792269 A＞G variant was an independent protective factor for good glycemic control(PSM-adjusted OR=0.478,95％CI 0.266-0.862,P＜0.05).In contrast,the SLC47A2 rs12943590 polymorphism showed no significant association with treatment efficacy.For the CAPN10 rs3792269 locus,the absolute difference in glycemic control rates between the two groups was 17.3％,with OR=2.10 and statistical power of approximately 90％.For the SLC47A2 rs12943590 locus,the absolute difference was 2.5％,with OR=0.91 and statistical power of only 7％.Conclusion This study clarifies that the CAPN10 rs3792269 A＞G variant is significantly associated with improved efficacy of metformin in the Xinjiang population of China,while the SLC47A2 rs12943590 locus shows no association in this sample.The influence of genetic factors on metformin efficacy exhibits population heterogeneity.The sample size in this study provids sufficient power for detecting moderate to large effects,which may serve as a reference for individualized medication and blood glucose management in local patients.关键词
二甲双胍/2型糖尿病/血糖控制/基因多态性/新疆人群Key words
metformin/type 2 diabetes/glycemic control/gene polymorphism/Xinjiang population分类
医药卫生引用本文复制引用
寇玉莲,马亮,李牧云,王钰博,冯文玲,阮洁,高晓黎,赵军..CAPN10 rs3792269和SLC47A2 rs12943590基因多态性与新疆地区T2DM患者二甲双胍疗效的关联性研究[J].中国临床药理学杂志,2025,41(23):3301-3308,8.基金项目
"天山英才"医药卫生高层次人才培养计划(TSYC202301A051) （TSYC202301A051）
新疆天然药物活性组分与释药技术重点实验室重点项目(2025XJTRZ03) （2025XJTRZ03）
新疆及中亚特色医药资源教育部工程研究中心定向资助项目(GC2X2024-03) （GC2X2024-03）
