中国临床药理学杂志2025，Vol.41Issue(23)：3309-3314,6.DOI:10.13699/j.cnki.1001-6821.2025.23.002
氟尿嘧啶类抗肿瘤药物致胃肠道毒性反应患者血清二胺氧化酶水平变化的临床研究
Clinical trial of changes and significance of serum diamine oxidase level in patients with gastrointestinal toxicity induced by fluorouracil antineoplastic drugs
黄孟芹 1胡丽霞 1李成发 1袁倩倩 1吴艳1
作者信息
- 1. 安徽医科大学附属合肥医院/合肥市第二人民医院血液肿瘤科,安徽 合肥 230011
- 折叠
摘要
Abstract
Objective To explore changes in serum diamine oxidase(DAO)levels and their clinical significance in patients with gastrointestinal toxicity induced by fluorouracil antineoplastic drugs.Methods Patients with gastrointestinal tumors receiving fluorouracil-based antineoplastic therapy were divided into treatment group and control group according to whether gastrointestinal toxicity occurred during chemotherapy.The treatment group was further subdivided into≤grade Ⅱ group and grade Ⅲ group based on the severity of gastrointestinal toxicity.General clinical data were collected,and serum DAO levels before chemotherapy and 7 days after chemotherapy were compared between treatment and control groups,as well as among patients with different grades of gastrointestinal toxicity.Logistic regression model was used to analyze the relationship between DAO levels and gastrointestinal toxicity,and receiver operating characteristic(ROC)curve analysis was performed to evaluate the predictive value of serum DAO levels 7 days after chemotherapy for the occurrence of gastrointestinal toxicity.Results A total of 50 patients were ultimately included as study subjects,with 26 in treatment group and 24 in control group.The serum DAO levels 7 days after chemotherapy were(14.71±3.44)and(10.89±3.67)U·L-1 in treatment and control groups,respectively.The serum DAO level in treatment group was significantly higher than that in control group 7 days after chemotherapy(P＜0.05).The serum DAO levels 7 days after chemotherapy in≤grade Ⅱ subgroup and grade Ⅲ subgroup were(13.38±3.06)and(16.37±3.25)U·L-1,respectively.The serum DAO level in the≤grade Ⅱ subgroup was significantly lower than that in the gradeⅢ subgroup(P＜0.05).Multivariate logistic regression analysis indicated that the serum DAO level 7 days after chemotherapy was an influencing factor for the occurrence of gastrointestinal toxicity in patients(P＜0.001).ROC curve analysis showed that the optimal threshold for serum DAO in predicting gastrointestinal toxicity after chemotherapy was 11.92 U·L-1,with an area under the curve(AUC)of 0.79(P＜0.05).The sensitivity and specificity were 77.78％and 86.96％,respectively.Conclusion Chemotherapy with fluorouracil-based antineoplastic drugs can lead to elevated serum DAO levels in patients with gastrointestinal tumors.The serum DAO level is associated with the severity of gastrointestinal toxicity and the grade of adverse drug reactions,and may serve as a predictive indicator for the occurrence of gastrointestinal toxicity following chemotherapy.关键词
氟尿嘧啶类抗肿瘤药物/消化道肿瘤/化学疗法/胃肠道毒性反应/二胺氧化酶/肠道屏障Key words
fluorouracil antineoplastic drug/gastrointestinal tumor/chemotherapy/gastrointestinal toxicity/diamine oxidase/intestinal barrier分类
医药卫生引用本文复制引用
黄孟芹,胡丽霞,李成发,袁倩倩,吴艳..氟尿嘧啶类抗肿瘤药物致胃肠道毒性反应患者血清二胺氧化酶水平变化的临床研究[J].中国临床药理学杂志,2025,41(23):3309-3314,6.
