中国畜牧兽医2026，Vol.53Issue(2)：555-563,9.DOI:10.16431/j.cnki.1671-7236.2026.02.004
阿苯达唑治疗囊型棘球蚴病的研究进展
Research Progress of Albendazole in the Treatment of Cystic Echinococcosis
摘要
Abstract
Cystic echinococcosis(CE),a severe zoonotic parasitic disease caused by the larval stage of Echinococcus granulosus(Eg),primarily affects human and livestock liver and lung tissues.Current treatment primarily involves surgical removal of cystic lesions combined with chemotherapy.However,traditional medications such as mebendazole(MBZ)and albendazole(ABZ)only inhibit parasite growth and reproduction without complete eradication,requiring long-term high-dose administration which can lead to adverse reactions including hepatotoxicity.Recent research has focused on novel ABZ formulations,delivery systems,and combination therapy strategies.Novel formulations and delivery methods aim to enhance efficacy by improving bioavailability and reducing toxicity:Emulsions and salt preparations optimize drug solubility,while ABZ combined with nanoparticles or carriers(liposomes and chitosan)creates targeted delivery systems that increase local drug concentration while minimizing systemic toxicity.Combination therapies demonstrate synergistic effects through multi-mechanism interference with parasite metabolism,combining ABZ with drugs such as praziquantel,flubendazole,and α-interferon.Despite these advances,no breakthrough therapeutic alternatives have emerged.This review summarizes the research progress of ABZ in treating CE,analyzing the advantages and limitations of various treatment approaches to provide a scientific basis for future drug development and clinical treatment optimization.关键词
囊型棘球蚴病(CE)/阿苯达唑(ABZ)/新型制剂/新型递送方式/联合用药Key words
cystic echinococcosis(CE)/albendazole(ABZ)/novel formulations/novel delivery methods/combination therapy分类
农业科技引用本文复制引用
宋润润,张欢,洛桑曲珍,次普赤,张念章..阿苯达唑治疗囊型棘球蚴病的研究进展[J].中国畜牧兽医,2026,53(2):555-563,9.基金项目
西藏自治区科技计划项目(QYXTZX-RKZ2024-03-3) （QYXTZX-RKZ2024-03-3）
