中国畜牧兽医2026，Vol.53Issue(2)：564-572,9.DOI:10.16431/j.cnki.1671-7236.2026.02.005
多酚缓解动物玉米赤霉烯酮肝脏毒性作用的研究进展
Research Progress on the Role of Polyphenols in Alleviating Zearalenone-induced Hepatotoxicity in Animals
摘要
Abstract
Zearalenone(ZEA),also known as F-2 toxin,is a type of mycotoxin with estrogenic toxicity produced by Fusarium species.It is commonly found in corn,wheat,soybean meal,and other grains and their by-products.After animals consume feed contaminated with ZEA,it can cause various toxic reactions.Among them,the liver,as the main metabolic and transformation organ of ZEA,is particularly vulnerable to damage.ZEA can easily induce oxidative stress,alterations in the expression of inflammation-related factors,and apoptosis of liver cells in the liver,thereby seriously endangering human and animal health.Polyphenols,as a class of plant chemical substances with strong antioxidant,antibacterial,anti-inflammatory and other biological activities,mainly include two categories:Flavonoids and non-flavonoids.The author selected rutin(RUT),a flavonoid,and curcumin(CUR),a non-flavonoid,as representative compounds to explain the mechanism by which polyphenols alleviate the liver toxicity induced by ZEA in animals.Both RUT and CUR can counteract the liver toxicity of ZEA through multi-target synergistic effects,mainly through antioxidant stress,anti-inflammatory and anti-apoptotic actions.The authors mainly reviewed the toxic effects of ZEA on animal livers and the mechanisms by which RUT and CUR alleviated ZEA induced animal liver toxicity,in order to provide a certain theoretical basis for subsequent research on polyphenols alleviating ZEA liver toxicity in animals and promoting the healthy development of animal husbandry.关键词
多酚/玉米赤霉烯酮/肝脏毒性/缓解机制Key words
polyphenols/zearalenone/hepatotoxicity/mechanism of alleviation分类
农业科技引用本文复制引用
李家慧,李浩男,杨凡,徐文静,陈晓光,张自强,刘玉梅,吕琼霞..多酚缓解动物玉米赤霉烯酮肝脏毒性作用的研究进展[J].中国畜牧兽医,2026,53(2):564-572,9.基金项目
河南省重点研发与推广专项(202102110093) （202102110093）
企业横向课题"一种缓解玉米赤霉烯酮对兔生长发育影响的硒代蛋氨酸饲料的开发"(22010154) （22010154）
