中国畜牧杂志2026，Vol.62Issue(2)：17-22,6.DOI:10.19556/j.0258-7033.20241212-03
干扰素tau(IFNT)的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用研究进展
Advances in the Structural Characteristics,Transcriptional Regulation Mechanisms and Applications of Interferon Tau in Ruminant Embryo Production
摘要
Abstract
Interferon tau(IFNT)is a type I interferon specifically secreted by the trophectoderm of ruminant embryos and plays a pivotal role during early pregnancy.Its primary functions include suppressing the synthesis and secretion of uterine prostaglandin F2α(PGF2α),thereby blocking luteolysis and ensuring sustained progesterone production.Additionally,IFNT exhibits anti-inflammatory,antiviral,and immunomodulatory properties that promote maternal immune tolerance,facilitating embryo implantation and development.The expression of IFNT is dynamically regulated by specific transcription factors and epigenetic modifications.In recent years,as the research on the molecular mechanisms of IFNT has advanced,its potential applications in enhancing reproductive efficiency and accelerating genetic improvement in ruminants have become increasingly evident.This review summarizes the structural characteristics,transcriptional regulatory mechanisms,and applications of IFNT in ruminant embryo production,aiming to provide a theoretical foundation for its practical utilization in ruminant reproductive biotechnology.关键词
IFNT/结构/抗黄体溶解/妊娠识别Key words
IFNT/Structure/Antiluteolysis/Pregnancy Recognition分类
农业科技引用本文复制引用
成元炜璐,庞洋,曾申明..干扰素tau(IFNT)的结构特征、转录调控机制及其在反刍动物胚胎生产中的应用研究进展[J].中国畜牧杂志,2026,62(2):17-22,6.基金项目
国家重点研发计划(2023YFD1300102-2) （2023YFD1300102-2）
宁夏回族自治区中央引导地方科技发展专项项目(2024FRD05031-01) （2024FRD05031-01）
