中国中西医结合急救杂志2025，Vol.32Issue(5)：539-543,5.DOI:10.3969/j.issn.1008-9691.2025.05.005
健脾止泻药食同源配方联合合生元干预对神经重症腹泻患者肠道菌群及腹泻症状的影响
Effects of a spleen-invigorating and antidiarrheal medicinal-food-homology formula combined with synbiotics on gut microbiota and diarrhea in neurologically ill patients
摘要
Abstract
Objective To investigate the effects of a combination of lotus seed powder,gordon euryale seed powder,and hyacinth bean powder together with synbiotics on diarrhea symptoms and gut microbiota in neurocritically ill patients,and to provide evidence for clinical nutritional intervention.Methods From June 2023 to December 2024,a total of 60 diarrhoeal patients admitted to Chenzhou First People's Hospital were enrolled as research subjects.The patients were randomly divided into an experimental group and a control group using a random number table method,with 30 patients in each group.All patients received routine treatment.In the control group,a synbiotic preparation was administered at a dose of 2 g per dose,twice daily,in addition to conventional treatment,either orally or via enteral tube.In the experimental group,on the basis of the control group treatment,an additional spleen-strengthening and antidiarrheal formula was administered,consisting of lotus seed powder(6 g),gorgon fruit powder(6 g),and hyacinth bean powder(6 g),three times daily,either orally or via enteral tube.Both groups were treated continuously for 14 days.Changes in nutritional indicators[including hemoglobin(Hb),albumin(Alb),and prealbumin(PA)],intestinal microbiota counts(including Escherichia coli,Lactobacillus,Bifidobacterium,and Enterococcus),and bowel movement characteristics(frequency,stool consistency,and stool volume)were observed before and after treatment.Results Before treatment,there were no statistically significant differences between the two groups in Hb,Alb,PA,stool frequency perday,Bristol Stool Form Scale score,stool volume,or the counts of each intestinal bacterial group(all P>0.05).After treatment,Hb and PA levels,as well as the counts of Lactobacillus and Bifidobacterium,were significantly increased in both groups compared with baseline,while stool frequency perday,Bristol Stool Form Scale score,stool volume,and the counts of Escherichia coli and Enterococcus were significantly decreased(all P<0.05).In the experimental group,Alb levels were significantly higher after treatment than before treatment(g/L:32.87±2.91 vs.32.16±3.13,P<0.05),whereas no significant difference in Alb levels was observed in the control group after treatment compared with baseline(P>0.05).Compared with the control group,the experimental group showed significantly higher Hb,PA levels and higher counts of Lactobacillus and Bifidobacterium after treatment[Hb(g/L):108.47±8.99 vs.103.40±15.05,PA(mg/L):144.87±34.01 vs.121.77±35.35,Lactobacillus count(log10 CFU/g):7.83±0.19 vs.7.34±0.21,Bifidobacterium count(log10 CFU/g):8.47±0.34 vs.7.47±0.33,all P<0.05].In addition,diarrhea duration,stool frequency perday,Bristol Stool Form Scale score,and the counts of Escherichia coli and Enterococcus were significantly lower in the experimental group than in the control group[diarrhea duration(days):2.73±1.01 vs.3.50±0.94,stool frequency perday(times):1.26±0.98 vs.2.13±0.89,Bristol Stool Form Scale score:2.87±1.85 vs.4.07±1.39,Escherichia coli count(log10 CFU/g):6.75±0.31 vs.8.12±0.26,Enterococcus count(log10 CFU/g):7.78±0.66 vs.8.20±0.72,all P<0.05].Conclusions The combination of lotus seed powder,Gordon euryale seed powder,and hyacinth bean powder,when used in conjunction with synbiotic intervention,can effectively shorten the duration of diarrhea in critically ill neurological patients,improve nutritional indicators,and significantly modulate the intestinal microbiota composition,demonstrating good clinical applicability and promising value for wider use.关键词
药食同源/合生元/肠内营养并发症/腹泻Key words
Homology of medicine and food/Synbiotics/Enteral nutrition complications/Diarrhea引用本文复制引用
徐大凤,王凯丁,李敏艳,谭莳芳,杨满梅..健脾止泻药食同源配方联合合生元干预对神经重症腹泻患者肠道菌群及腹泻症状的影响[J].中国中西医结合急救杂志,2025,32(5):539-543,5.基金项目
湖南省中医药管理局科研项目(D2024057) Hunan Province Traditional Chinese Medicine Scientific Research Project(D2024057) （D2024057）
