中国中西医结合急救杂志2025，Vol.32Issue(5)：550-555,6.DOI:10.3969/j.issn.1008-9691.2025.05.007
基于"正邪交争"理论分析不同年龄段肺炎患者临床特征的差异
Study on the difference in clinical characteristics of pneumonia patients across age groups based on the theory of"conflict between healthy qi and pathogenic qi"
摘要
Abstract
Objective To analyze differences in clinical characteristics of pneumonia patients across age groups based on the theory of"conflict between healthy qi and pathogenic qi".Methods Patients diagnosed with pneumonia at the fever clinic of Beijing Hospital of Traditional Chinese Medicine,Capital Medical University from 20 January 2021(Great Cold)to 20 January 2022(Great Cold)were selected as the study subjects.Based on the theory of"healthy qi",patients were divided into 4 age groups[Group 1(14-32 years),Group 2(33-48 years),Group 3(49-64 years),and Group 4(≥65 years)].The following macro-signs were compared among the groups:macroscopic signs(peak body temperature),inflammatory indicators reflecting the degree of evil qi[white blood cell count(WBC),neutrophil count(NEU),neutrophil percentage(NEU%),C-reactive protein(CRP)],immune indicators reflecting the degree of healthy qi deficiency[lymphocyte count(LYM),lymphocyte percentage(LYM%)],the neutrophil/lymphocyte ratio(NLR)reflecting the contrast between pathogenic and healthy qi;and the level of platelet count(PLT)indicating the trend of progression to severe disease(entering the nutrient and blood aspects).Results A total of 446 pneumonia patients were admitted throughout the year.After excluding cases with missing data,377 cases were finally included:49 cases in Group 1,57 cases in Group 2,76 cases in Group 3,and 195 cases in Group 4.No statistically significant difference was found in peak body temperature among the four groups.With increasing age,WBC,NEU,NEU%,CRP,and NLR gradually increased,while LYM,LYM%,and PLT gradually decreased.Compared with Group 1,Groups 4 showed significant increases in WBC,NEU,NEU%,CRP,and NLR[WBC(×109/L):10.6(8.2,14.4)vs.8.2(6.1,11.2),NEU(×109/L):8.9(6.5,13.0)vs.6.4(4.1,9.0),NEU%:85.9(80.1,90.2)vs.75.5(69.7,83.6),CRP(mg/L):57.4(18.2,123.8)vs.12.6(4.2,29.6),NLR:11.1(6.3,18.9)vs.4.8(3.4,9.7),all P<0.05],and significant decreases in LYM,LYM%,and PLT[LYM(×109/L):0.9(0.5,1.2)vs.1.1(0.8,1.8),LYM%:7.9(4.9,12.8)vs.15.4(8.8,20.6);PLT(×109/L):196.0(145.0,250.0)vs.227.0(190.0,272.5),all P<0.05].Compared with Group 2,Group 4 showed significant increases in NEU,NEU%,CRP,and NLR[NEU(×109/L):8.9(6.5,13.0)vs.7.7(5.4,10.1),NEU%:85.9(80.1,90.2)vs.77.9(71.7,82.0),CRP(mg/L):57.4(18.2,123.8)vs.17.7(8.3,64.1),NLR:11.1(6.3,18.9)vs.5.2(3.8,7.1),all P<0.05],and significant decreases in LYM and LYM%[LYM(×109/L):0.9(0.5,1.2)vs.1.4(1.1,1.8),LYM%:7.9(4.9,12.8)vs.14.2(11.2,19.2),both P<0.05].Compared with Group 3,Group 4 showed significant increases in CRP and NLR[CRP(mg/L):57.4(18.2,123.8)vs.52.2(16.1,100.3),NLR:11.1(6.3,18.9)vs.6.9(4.7,10.3),both P<0.05].Conclusions Clinical characteristics of pneumonia patients vary significantly across different age groups.This is mainly manifested by higher inflammatory indicators(more intense pathogenic qi)and lower immune indicators(more deficient healthy qi)in older patients,showing a more significant trend of excessive evil qi and deficient healthy qi,making the condition more prone to progression.关键词
肺炎/年龄/中医/正气Key words
Pneumonia/Age/Traditional Chinese medicine/Healthy qi引用本文复制引用
陈腾飞,高子恒,徐霄龙,曲志成,郭伟,刘清泉..基于"正邪交争"理论分析不同年龄段肺炎患者临床特征的差异[J].中国中西医结合急救杂志,2025,32(5):550-555,6.基金项目
北京市医院管理中心青年人才培养"青苗"计划(QML20231007) （QML20231007）
中华中医药学会雏鹰计划中医青年临床人才研修项目(CYJH2024006) Beijing Municipal Hospital Administration Center Young Talent Training"Green Seedling"Program(QML20231007) （CYJH2024006）
China Association of Chinese Medicine"Young Eagle"Program for Advanced Studies of Young Clinical Talents of Traditional Chinese Medicine(CYJH2024006) （CYJH2024006）
